Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.
Catherine Amaya,Christopher J. F. Cameron,Swapnil C. Devarkar,Sebastian J.H. Seager,Mark Gerstein,Yong Xiong,Christian Schlieker +6 more
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TLDR
In this article, the authors performed a proteomic screen and identified nodal modulator (NOMO), a widely conserved type I transmembrane protein of unknown function, with three nearly identical orthologs specified in the human genome.About:
This article is published in Journal of Biological Chemistry.The article was published on 2021-08-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Sequestosome 1 & Unfolded protein response.read more
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Quality control mechanisms that protect nuclear envelope identity and function
Philip Mannino,C. Patrick Lusk +1 more
TL;DR: The most recent work exploring nuclear envelope quality control mechanisms across eukaryotes is synthesized, finding specializations of cellular degradative machineries tailored to meeting the unique challenges imposed by the NE.
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Biological Role of Nodal Modulator: A Comprehensive Review of the Last Two Decades.
Yuhui Sun,Tao Li,Xin Qian +2 more
TL;DR: The role of NOMO in different diseases and the mechanism underlying its effects remains unknown are reviewed and investigated.
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Dynamics of CLIMP-63 S-acylation control ER morphology
Patrick A. Sandoz,Robin A. Denhardt-Eriksson,Laurence Abrami,Luciano A. Abriata,Gard Spreemann,Catherine Maclachlan,Sylvia Ho,Beat Kunz,Kathryn S. Hess,Graham Knott,Francisco S Mesquita,Vassily Hatzimanikatis,F. Gisou van der Goot +12 more
TL;DR: In this paper , the impact of S-acylation, a reversible post-translational lipid modification, on CLIMP-63 cellular distribution and function was analyzed using super-resolution microscopy and focused ion beam electron microscopy.
References
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The Phyre2 web portal for protein modeling, prediction and analysis
Lawrence A. Kelley,Stefans Mezulis,Christopher M. Yates,Christopher M. Yates,Mark N. Wass,Mark N. Wass,Michael J.E. Sternberg +6 more
TL;DR: An updated protocol for Phyre2, which uses advanced remote homology detection methods to build 3D models, predict ligand binding sites and analyze the effect of amino acid variants for a user's protein sequence.
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RELION: implementation of a Bayesian approach to cryo-EM structure determination.
TL;DR: Developments that reduce the computational costs of the underlying maximum a posteriori (MAP) algorithm, as well as statistical considerations that yield new insights into the accuracy with which the relative orientations of individual particles may be determined are described.
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The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter,David Ron +1 more
TL;DR: The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum, where they fold and assemble, and only properly assembled proteins advance from the ER to the cell surface.
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EMAN2: an extensible image processing suite for electron microscopy.
Guang Tang,Liwei Peng,Philip R. Baldwin,Deepinder S. Mann,Wen Jiang,I. Rees,Steven J. Ludtke +6 more
TL;DR: EMAN2 has been under development for the last two years, with a completely refactored image processing library, and a wide range of features to make it much more flexible and extensible than EMAN1.
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Roles of N-Linked Glycans in the Endoplasmic Reticulum
Ari Helenius,Markus Aebi +1 more
TL;DR: From a process involved in cell wall synthesis in archaea and some bacteria, N-linked glycosylation has evolved into the most common covalent protein modification in eukaryotic cells.
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