Journal ArticleDOI
Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings.
TLDR
In this article, the ultrastructural and immunohistologic findings in a nodular variant of Hodgkin's disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers.Abstract:
Ultrastructural and immunohistologic findings in a nodular variant of Hodgkin’s disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers. These are large follicles with numerous lymphocytes which can be found not only in nonspecific lymphadenitis, but also in lymph nodes from patients with nodular paragranuloma. The immunoperoxidase technique was applied on paraffin sections to detect intracytoplasmic immunoglobulin and lysozyme. The so-called L & H type Sternberg-Reed cells contained IgG and one type of light chain per cell, suggesting that such cells produce immunoglobulin. The ultrastructure of the L & H type Sternberg-Reed cells favored the immunoblastic nature of these cells. It is concluded that nodular paragranuloma differs from other types of Hodgkin’s disease by its localization in B-cell areas and the presence of atypical B immunoblasts.read more
Citations
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Journal ArticleDOI
Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells
Ulrich Schwab,Harald Stein,J. Gerdes,Hilmar Lemke,Hartmut Kirchner,Michael Schaadt,Volker Diehl +6 more
TL;DR: Production of mouse monoclonal antibodies against the Hodgkin cell line L428 was described and one hybridoma antibody was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.
Journal ArticleDOI
Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population
Harald Stein,Johannes Gerdes,Ulrich Schwab,Hilmar Lemke,David Y. Mason,Andreas Ziegler,Wolfgang Schienle,Volker Diehl +7 more
TL;DR: It is suggested that the hitherto unknown cell population detected with the monoclonal antibody Ki‐I in normal lymphoid tissue is the normal equivalent of H and SR cells.
Journal ArticleDOI
The normal and malignant germinal centre.
Journal ArticleDOI
European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes
Ioannis Anagnostopoulos,Martin-Leo Hansmann,Kaarle Franssila,Martin Harris,Nancy L. Harris,Elaine S. Jaffe,J. Han,J. M. van Krieken,Sibrand Poppema,Teresa Marafioti,Jeremy Franklin,M Sextro,Volker Diehl,Harald Stein +13 more
TL;DR: Clinically, patients with LPHD and NLRCHD showed similar disease characteristics at presentation but differed in the frequency of multiple relapses and prognosis after relapse, and how frequent T-cell-rich large B-cell lymphoma (TCRLBCL) is among LPHD, and found differential diagnostic criteria distinguishing between the 2 lymphoma categories.
Journal ArticleDOI
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
TL;DR: Analysis of sequential biopsies from patients with recurrent disease suggests that the presence of prominent extranodular L&H cells might represent early evolution to a diffuse (TCRBCL-like) pattern of NLPHL.
References
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Journal Article
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