Journal ArticleDOI
Non-coding RNAs and macrophage interaction in tumor progression.
Maliheh Entezari,Mehrdokht Sadrkhanloo,Mohsen Rashidi,Sholeh Etehad Asnaf,Afshin Taheriazam,M. Hashemi,Milad Ashrafizadeh,Ali Zarrabi,Navid Rabiee,Kiavash Hushmandi,Sepideh Mirzaei,Gautam Sethi +11 more
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TLDR
In this paper , the role of non-coding RNAs (ncRNAs) and exosomal ncRNAs derived from tumor cells or macrophages can be considered as non-invasive biomarkers for tumor diagnosis.Abstract:
The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by affecting various molecular pathways, they modulate tumor progression and therapy response. The lncRNAs can affect miRNAs via sponging and other molecular pathways to modulate macrophage polarization. A few experiments have also examined role of circRNAs in targeting signaling networks and affecting macrophages. The therapeutic targeting of these ncRNAs can mediate TME remodeling and affect macrophage polarization. Furthermore, exosomal ncRNAs derived from tumor cells or macrophages can modulate polarization and TME remodeling. Suppressing biogenesis and secretion of exosomes can inhibit ncRNA-mediated M2 polarization of macrophages and prevent tumor progression. The ncRNAs, especially exosomal ncRNAs can be considered as non-invasive biomarkers for tumor diagnosis. read more
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LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions.
Maliheh Entezari,Afshin Taheriazam,Sima Orouei,Shayan Fallah,Arezoo Sanaei,Elahe Sadat Hejazi,Amirabbas Kakavand,Shamin Rezaei,Hajar Heidari,Mitra Behroozaghdam,Salman Daneshi,Shokooh Salimimoghadam,Sepideh Mirzaei,M. Hashemi,Saeed Samarghandian +14 more
TL;DR: In this paper , a review focused on the lncRNA-miRNA axis in malignancy and therapy resistance of tumors, which can be considered as a signature for diagnosis and prognosis in cancers.
Journal ArticleDOI
Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance.
M. Hashemi,Shima Hajimazdarany,Chakrabhavi Dhananjaya Mohan,Maryam Mohammadi,Shamin Rezaei,Yeganeh Olyaee,Yeganeh Goldoost,Amin Ghorbani,Seyed Reza Mirmazloomi,Nazanin Gholinia,Amirabbas Kakavand,Shokooh Salimimoghadam,Yavuz Nuri Ertas,Kanchugarakoppal S. Rangappa,Afshin Taheriazam,Maliheh Entezari +15 more
TL;DR: In this article , the authors comprehensively discussed the oncogenic and tumor suppressor role of lncRNAs and their mechanism of action in the regulation of the epithelial-to-mesenchymal transition (EMT) process in various cancers such as brain tumors, gastrointestinal tumors, and gynecological and urological tumors.
Journal ArticleDOI
The multi-molecular mechanisms of tumor-targeted drug resistance in precision medicine.
Xinming Li,Mingdong Li,Meiying Huang,Qianyi Lin,Qiuping Fang,Jianjiang Liu,Xiaohui Chen,Lin Liu,Xuliang Zhan,Huisi Shan,Deshuai Lu,Qinlan Li,Zesong Li,Xiao Zhu +13 more
TL;DR: In this paper , a review of the multi-molecular mechanisms of drug resistance is introduced, and the overcoming of drug resistant is discussed from the perspective of the tumor microenvironment.
Journal ArticleDOI
Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response.
Milad Ashrafizadeh,Chakrabhavi Dhananjaya Mohan,Shobith Rangappa,Ali Zarrabi,Kiavash Hushmandi,Alan Prem Kumar,Gautam Sethi,Kanchugarakoppal S. Rangappa +7 more
TL;DR: In this article , the tumor-promoting role of non-coding RNAs (ncRNAs) in the regulation of the STAT3 pathway has been discussed and comprehensively discussed.
Journal ArticleDOI
Targeting PD-1/PD-L1 axis as new horizon for ovarian cancer therapy.
Elina Khatoon,Dey Parama,Aviral Kumar,Mohammed Alqahtani,Sosmitha Girisa,Gautam Sethi,Ajaikumar B. Kunnumakkara +6 more
TL;DR: In this paper , the authors provide an overview of the PD-1/PD-L1 axis and role of non-coding RNAs in regulating this axis and discuss the limitations of immunotherapies in ovarian cancer.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Most mammalian mRNAs are conserved targets of microRNAs
TL;DR: This work overhauled its tool for finding preferential conservation of sequence motifs and applied it to the analysis of human 3'UTRs, increasing by nearly threefold the detected number of preferentially conserved miRNA target sites.
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Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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