Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells
Michael H. Carstens,Michael H. Carstens,Arturo Gómez,Ronald Cortés,Elizabeth E. Turner,Cecilia Pérez,Marlon Ocon,Diego Correa +7 more
TLDR
The utility of non-expanded adipose-derived heterogeneous SVF cell population processed at the point-of-care, to treat patients with end-stage PVD as an alternative to palliation or amputation is highlighted.About:
This article is published in Stem Cell Research.The article was published on 2017-01-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Adipose-derived Stromal Vascular Fraction Cells & Stromal vascular fraction.read more
Citations
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Journal ArticleDOI
Stromal vascular fraction technologies and clinical applications
TL;DR: SVF provides a cellular and molecular microenvironment for regulation of ASC’ activities under different clinical conditions and novel point of care methods are emerging to refine SVF in ways that meet the regulatory requirements for minimal manipulation.
Journal ArticleDOI
Adipose-derived stem cells for treatment of chronic ulcers: current status
TL;DR: Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers, as these results are consistent despite the shortcomings of the studies, and appear to highlight the efficacy of ADSC in the treatment of chronic ulcers.
Journal ArticleDOI
Vasculogenic and angiogenic potential of adipose stromal vascular fraction cell populations in vitro.
TL;DR: An in vitro system that provides a functional assay to study the mechanisms of vasculogenesis and angiogenesis in freshly isolated SVF to characterize SVF’s blood vessel forming potential prior to clinical implantation is created.
Journal ArticleDOI
Treatment of chronic diabetic foot ulcers with adipose-derived stromal vascular fraction cell injections: Safety and evidence of efficacy at 1 year.
Michael H. Carstens,Francisco J. Quintana,Santos T. Calderwood,Juan P. Sevilla,Arlen B. Ríos,Carlos M. Rivera,Dorian W. Calero,María L. Zelaya,Nelson Garcia,Kenneth A. Bertram,Joseph Rigdon,Severiano Dos-Anjos,Diego Correa +12 more
TL;DR: In this article, the authors used autologous adipose-derived stromal vascular fraction (SVF) cells to treat nonhealing diabetic foot ulcers (DFUs) greater than 3 cm in diameter.
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Possibility of Injecting Adipose-Derived Stromal Vascular Fraction Cells to Accelerate Microcirculation in Ischemic Diabetic Feet: A Pilot Study.
TL;DR: Results of this study demonstrate that adipose-derived SVF cell injection have the possibility to provide beneficial effects on microcirculation in ischemic diabetic feet.
References
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Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
TL;DR: The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.
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Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
Lars Norgren,William R. Hiatt,John A. Dormandy,Mark R. Nehler,Kenneth A. Harris,F. G. R. Fowkes +5 more
TL;DR: The goals of this new consensus are to provide an abbreviated document to focus on key aspects of diagnosis and management, and to update the information based on new publications and the newer guidelines, but not to add an extensive list of references.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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Recommended standards for reports dealing with lower extremity ischemia: Revised version
TL;DR: This report attempts to correct shortcomings while reinforcing those recommendations that have proven satisfactory on lower extremity ischemia and is intended to replace the original version.
Journal ArticleDOI
Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.