Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol
S. Ferrari,K. Sundby Hall,Roberto Luksch,Amelia Tienghi,Thomas Wiebe,Franca Fagioli,Thor Alvegård,A. Brach del Prever,A. Tamburini,Marco Alberghini,Lorenza Gandola,Mario Mercuri,R. Capanna,S Mapelli,Arcangelo Prete,Modesto Carli,P. Picci,Enza Barbieri,G. Bacci,Sigbjørn Smeland +19 more
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TLDR
High-dose therapy added to the VACA-IE regimen in PR patients is feasible and effective and Selected groups of patients with ES can benefit from HDT.About:
This article is published in Annals of Oncology.The article was published on 2011-05-01 and is currently open access. It has received 107 citations till now. The article focuses on the topics: Chemotherapy regimen & Induction chemotherapy.read more
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Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Paolo G. Casali,J.-Y. Blay +1 more
TL;DR: The following recommendations apply to adult-type soft tissue sarcomas arising from limbs and superficial trunk and Extraskeletal Ewing sarcoma, which is excluded from this chapter.
Journal ArticleDOI
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration
Nathalie Gaspar,Douglas S. Hawkins,Uta Dirksen,Ian Lewis,Stefano Ferrari,Marie-Cécile Le Deley,Marie-Cécile Le Deley,Heinrich Kovar,R Grimer,Jeremy Whelan,Jeremy Whelan,Line Claude,Olivier Delattre,Michael Paulussen,Piero Picci,Kirsten Sundby Hall,Hendrik van den Berg,Ruth Ladenstein,Jean Michon,Lars Hjorth,Ian Judson,Ian Judson,Roberto Luksch,Mark L. Bernstein,Perrine Marec-Berard,Bernadette Brennan,Alan W. Craft,Richard B. Womer,Heribert Juergens,Odile Oberlin +29 more
TL;DR: The many insights into the biology of the EWS-FLI1 protein in the initiation and progression of ES remain to be translated into novel therapeutic strategies and current options and future approaches will be discussed.
Journal Article
Bone Sarcomas : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 25, pg iii113, 2014)
J.-Y. Blay,Alexia Bertuzzi,Stefan S. Bielack,Bodil Bjerkehagen,S. Bonvalot,Ioannis Boukovinas,Paolo Bruzzi,A. P. Dei Tos,P. Dileo,Mikael Eriksson,A. Fedenko,Andrea C. Ferrari,Silvia Ferrari,Hans Gelderblom,R. J. Grimer,Alessandro Gronchi,R. L. Haas,Kirsten Sundby Hall,Peter Hohenberger,Rolf-Dieter Issels,Heikki Joensuu,Ian Judson,A. Le Cesne,S. Litiere,J. Martin-Broto,Ofer Merimsky,Michael Montemurro,Carlo Morosi,P. Picci,I.L. Ray-Coquard,Peter Reichardt,Piotr Rutkowski,Marcus Schlemmer,Silvia Stacchiotti,Valter Torri,Annalisa Trama,F. van Coevorden,Daniel Vanel,Eva Wardelmann,Paolo G. Casali +39 more
TL;DR: Osteosarcoma and Ewing sarcoma have a relatively high incidence in the second decade of life, while chondrosarcomas are more common in older age groups, and chordomas are rare; arising with an incidence of ∼0.5/ million population per year.
Journal ArticleDOI
Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
Paolo G. Casali,Stefan S. Bielack,N. Abecassis,Hannu T. Aro,Sebastian Bauer,R. Biagini,Sylvie Bonvalot,Ioannis Boukovinas,Judith V.M.G. Bovée,Bernadette Brennan,Thomas Brodowicz,Javier Martin Broto,Laurence Brugières,Angela Buonadonna,E. de Álava,A. P. Dei Tos,X.G. del Muro,Palma Dileo,Catharina Dhooge,Mikael Eriksson,Franca Fagioli,Alexander Fedenko,Virginia Ferraresi,Andrea Ferrari,S. Ferrari,A.M. Frezza,Nathalie Gaspar,Silvia Gasperoni,Hans Gelderblom,Thierry Gil,Giovanni Grignani,Alessandro Gronchi,Rick L. Haas,B. Hassan,Stefanie Hecker-Nolting,Peter Hohenberger,Rolf D. Issels,Heikki Joensuu,Robin L. Jones,Ian Judson,Paul C Jutte,Suzanne E. J. Kaal,Leo Kager,Bernd Kasper,Katerina Kopeckova,D.A. Krakorova,Ruth Ladenstein,A. Le Cesne,Iwona Lugowska,Ofer Merimsky,Michael Montemurro,Bruce Morland,Maria Abbondanza Pantaleo,R. Piana,P. Picci,S. Piperno-Neumann,Antonio López Pousa,Peter Reichardt,M.H. Robinson,Piotr Rutkowski,Akmal Safwat,Patrick Schöffski,Stefan Sleijfer,Silvia Stacchiotti,Sandra J. Strauss,K. Sundby Hall,M. Unk,F. van Coevorden,W.T.A. van der Graaf,W.T.A. van der Graaf,W.T.A. van der Graaf,Jeremy Whelan,Eva Wardelmann,Olga Zaikova,Jean-Yves Blay +74 more
TL;DR: Primary bone tumours are rare, accounting for < 0.2% of malignant neoplasms registered in the EUROCARE (European Cancer Registry based study on survival and care of cancer patients) database, and different bone tumour subtypes have distinct patterns of incidence.
Journal ArticleDOI
UK guidelines for the management of bone sarcomas
Craig Gerrand,Nicholas A. Athanasou,Bernadette Brennan,Robert J. Grimer,Ian Judson,Bruce Morland,David Peake,Beatrice Seddon,Jeremy Whelan +8 more
TL;DR: This document is an update of the British Sarcoma Group guidelines and recommends that patients with clinico-radiological findings suggestive of a primary bone tumour at any site in the skeleton should be referred to a specialist centre and managed by a fully accredited bone sarcoma multidisciplinary team.
References
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A system for the surgical staging of musculoskeletal sarcoma.
TL;DR: A surgical staging system for musculoskeletal sarcomas stratifies bone and soft-tissue lesions of any histogenesis by the grade of biologic aggressiveness, by the anatomic setting, and by the presence of metastasis, which permits appropriate evaluation and comparison of the new treatment protocols designed to replace standard surgical treatment.
Journal ArticleDOI
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
Holcombe E. Grier,Mark Krailo,Nancy J. Tarbell,Michael P. Link,Chris Fryer,Douglas J. Pritchard,Mark C. Gebhardt,Paul S. Dickman,Elizabeth J. Perlman,Paul A. Meyers,Sarah S. Donaldson,Sheila Moore,Aaron R. Rausen,Teresa J. Vietti,James S. Miser +14 more
TL;DR: The addition of ifosfamide and etoposide to a standard regimen does not affect the outcome for patients with metastatic disease, but it significantly improves the outcomeFor patients with nonmetastatic Ewing's Sarcoma, primitive neuroectodermal tumor of bone, or primitive sarcoma of bone.
Journal ArticleDOI
Prognostic Factors in Ewing’s Tumor of Bone: Analysis of 975 Patients From the European Intergroup Cooperative Ewing’s Sarcoma Study Group
Simon Cotterill,S. Ahrens,Michael Paulussen,Heribert Jürgens,P. A. Voûte,H. Gadner,Alan W. Craft +6 more
TL;DR: Survival and RFS improved over the period and radiotherapy or amputation were more common in the period before 1986, whereas endoprosthetic surgery was widely used in the later period.
Journal ArticleDOI
Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study.
Mark E. Nesbit,Edmund A. Gehan,Burgert Eo,Teresa J. Vietti,Ayten Cangir,M Tefft,Richard G. Evans,Patrick R.M. Thomas,Frederic B. Askin,John M. Kissane +9 more
TL;DR: A total of 342 previously untreated eligible children were entered into the first Intergroup Ewing's Sarcoma Study (IESS) between May 1973 and November 1978 and patient characteristics related to prognosis and overall survival experience were primary site (nonpelvic patients were most favorable) and patient age (younger patients were more favorable).
Journal ArticleDOI
Ewing’s Sarcoma Family of Tumors: Current Management
Mark L. Bernstein,Heinrich Kovar,Michael Paulussen,R. L. Randall,Andreas Schuck,Lisa A. Teot,Herbert Juergens +6 more
TL;DR: Patients with initially metastatic disease fare less well, with about one quarter surviving, and new approaches include anti-angiogenic therapy, particularly since vascular endothelial growth factor is an apparent downstream target of the ews-fli1 oncogene.
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Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
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Linda Granowetter,Richard B. Womer,Meenakshi Devidas,Mark Krailo,Chenguang Wang,Mark Bernstein,Neyssa Marina,Patrick J. Leavey,Mark C. Gebhardt,John H. Healey,Robert C. Shamberger,Allen M. Goorin,James S. Miser,James O. Meyer,Carola A.S. Arndt,Scott L. Sailer,Karen J. Marcus,Elizabeth J. Perlman,Paul W. Dickman,Holcombe E. Grier +19 more