Journal ArticleDOI
Novel pH-Sensitive Hydrogels Prepared from the Blends of Poly(vinyl alcohol) with Acrylic Acid-graft-Guar Gum Matrixes for Isoniazid Delivery
TLDR
In this paper, a pH-sensitive hydrogel blend of polyvinyl alcohol with acrylic acid-graft-guar gum has been prepared for the controlled release of an antituberculosis drug, isoniazid.Abstract:
A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of ∼10 μm were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5−1.6 h.read more
Citations
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Guar gum as a promising starting material for diverse applications: A review.
TL;DR: An overview of the nature, chemistry and properties of guar gum is given and recent developments in its modifications and applications in major industries like hydraulic fracturing, explosives, food, agriculture, textile, paper, cosmetics, bioremediation, drug delivery, medical and pharmaceuticals are discussed.
Journal ArticleDOI
Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release
TL;DR: In this article, a pH-sensitive cross-linked AA/Gelatin hydrogel was synthesized by free radical polymerization, where Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as cross-linking agent, respectively.
Journal ArticleDOI
A review on biomacromolecular hydrogel classification and its applications.
Swati Sharma,Shachi Tiwari +1 more
TL;DR: The polymeric material exhibiting multi-responsive properties such as swelling, pH responsive, mechanically strong, self-healing, flexible plays vital role in different applications and is summarized in this review.
Journal ArticleDOI
Influence of polymer network parameters of tragacanth gum-based pH responsive hydrogels on drug delivery
Baljit Singh,Vikrant Sharma +1 more
TL;DR: It has been observed that release profile of amoxicillin best followed the first order model for the release of drug from the polymer matrix through non-Fickian diffusion mechanism in pH 7.4 solution.
Journal ArticleDOI
Water retention and dye adsorption behavior of Gg-cl-poly(acrylic acid-aniline) based conductive hydrogels
TL;DR: In this paper, a novel poly(acrylic acid-aniline)-grafted gum ghatti based conducting hydrogel was synthesized by a simple two-step method.
References
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A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
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Polysaccharides-based nanoparticles as drug delivery systems
TL;DR: In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crossl linking, polyelectrolyte complex, and the self-assembly of hydrophobically modified poly Saccharides.
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Chemical modification of chitosan and equilibrium study for mercury ion removal
Choong Jeon,Wolfgang H. Höll +1 more
TL;DR: To increase the uptake capacity of mercury ions, several chemical modifications of chitosan beads which are cross-linked with glutaraldehyde were performed and they showed the characteristic of competitive sorption between mercury and hydrogen ions and it was successfully modelled by an equilibrium model.