Journal ArticleDOI
Novel symmetrical and unsymmetrical fluorine-containing metallophthalocyanines: synthesis, characterization and investigation of their biological properties.
TLDR
In this article, a new fluorinated phthalonitrile compound namely 5-bis[4-(trifluoromethoxy)-thiophenyl] phthaloniitrile was synthesized and the results indicated that the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity was determined to be 67.85% for 2 and also 3 showed the highest activity with 31.65% for chelating activity at 200 mg L−1 concentration.Abstract:
In this study, a new fluorinated phthalonitrile compound namely 5-bis[4-(trifluoromethoxy)-thiophenyl] phthalonitrile was synthesized. In addition, peripherally substituted symmetric metallated phthalocyanine derivatives [M = Co (2) and M = Zn (3)] and unsymmetrically substituted zinc phthalocyanine (ZnPc) complex (4) were synthesized by cyclotetramerization of this phthalonitrile compound. Characterization of all new compounds was carried out using FT-IR, NMR, UV-Vis, and mass spectroscopy. Additionally, antioxidant activity, DNA cleavage activity, antimicrobial activity, biofilm inhibition activity, and bacterial viability inhibition test of the compounds (1–4) were investigated. The antioxidant activities of the new phthalocyanine complexes were studied by performing two different methods. The results indicated that the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity was determined to be 67.85% for 2 and also 3 showed the highest activity with 31.65% for chelating activity at 200 mg L−1 concentration. Phthalocyanine compounds demonstrated effective DNA cleavage and antimicrobial activities. The highest percentage of cell vitality inhibition was found for compound 4, 56.92%. Also, test compounds exhibited good biofilm inhibition activity.read more
Citations
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Journal ArticleDOI
Photophysicochemical, sonochemical, and biological properties of novel hexadeca-substituted phthalocyanines bearing fluorinated groups.
Nazli Farajzadeh,Çetin Çelik,Göknur Yaşa Atmaca,Sadin Özdemir,Serpil Gonca,Ali Erdoğmuş,Makbule Burkut Koçak +6 more
TL;DR: In this paper, a tetra-substituted phthalonitrile (TSP) was used for photodynamic and sonophotodynamic therapies for the treatment of infectious diseases.
Journal ArticleDOI
Photophysicochemical, sonochemical, and biological properties of novel hexadeca-substituted phthalocyanines bearing fluorinated groups
TL;DR: In this paper , a tetra-substituted phthalonitrile (TSP) was used for photodynamic and sonophotodynamic therapies for the treatment of infectious diseases.
Journal ArticleDOI
Biological properties of hexadeca-substituted metal phthalocyanines bearing different functional groups.
TL;DR: In this article , a tetra-substituted phthalonitrile (diethyl 2-(2-chloro-4,5-dicyano-3,6-bis(hexyloxy)phenyl)malonate) bearing three different substituents was synthesized and characterized.
Journal ArticleDOI
Phenolic compounds recovery from pistachio hull using pressure-driven membrane process and a cleaner production of biopesticide
TL;DR: In this paper, a pressure-driven membrane process was used to concentrate phenolic compounds from water used as a solvent and the contents of the recovered compounds in permeate and concentrate streams were determined by LC-MSMS.
Journal ArticleDOI
Photophysicochemical and Biological Properties of New Phthalocyanines Bearing 4-(trifluoromethoxy)phenoxy and 2-(4-methylthiazol-5-yl)ethoxy Groups on Peripheral Positions.
Nazli Farajzadeh,Sadin Özdemir,Serpil Gonca,Göknur Yaşa Atmaca,Ali Erdoğmuş,Zehra Altuntaş Bayır,Makbule Burkut Koçak +6 more
TL;DR: In this paper, the synergic effect of thiazoles and fluorinated groups on the biological features of phthalocyanines for the first time was evaluated in the hope of discovering efficient pharmaceutical agents.
References
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A Simple Synthesis of 4,5-Disubstituted 1,2-Dicyanobenzenes and 2,3,9,10,16,17,23,24-Octasubstituted Phthalocyanines
TL;DR: In this paper, 4,5-Dichloro-1,2-dicyanobenzene (5) was prepared with phenols, thiophenol and 1-propanethiol and showed high yields to octasubstituted phthalocyanines (tetrabenzoporphyrazines).
Journal ArticleDOI
The Pi electron structure and absorption spectra of chlorophylls in solution
TL;DR: In this paper, a detailed comparison of absorption, fluorescence polarization, circular dichroism (CD), and magnetic circular dichromism (r.lCD) spectr:a in the visible and ultra-violet with the well understood spectra of the unsubstituted parent rtngs is presented.