Journal ArticleDOI
Photophysicochemical, sonochemical, and biological properties of novel hexadeca-substituted phthalocyanines bearing fluorinated groups.
Nazli Farajzadeh,Çetin Çelik,Göknur Yaşa Atmaca,Sadin Özdemir,Serpil Gonca,Ali Erdoğmuş,Makbule Burkut Koçak +6 more
TLDR
In this paper, a tetra-substituted phthalonitrile (TSP) was used for photodynamic and sonophotodynamic therapies for the treatment of infectious diseases.Abstract:
This study presents the preparation of a novel tetra-substituted phthalonitrile (1), namely, 3,6-bis(hexyloxy)-4,5-bis(4-(trifluoromethoxy)phenoxy)phthalonitrile (1) and its metal-free (2)/metal {M = Zn (3), Cu (4), Co (5), Lu(CH3COO) (6), Lu (7)} phthalocyanines. A series of various spectroscopic methods (UV-vis, FT-IR, mass, and 1H NMR spectroscopy) were performed for the characterization of the newly synthesized compounds. The potential of compounds 2, 3, and 6 as photosensitizing materials for photodynamic and sonophotodynamic therapies was evaluated by photophysical, photochemical, and sonochemical methods. The highest singlet quantum yields were obtained for the zinc phthalocyanine derivative 3 by performing photochemical and sonochemical methods. In addition, several biological activities of the new compounds 1–7 were investigated. The newly synthesized phthalocyanines exhibited excellent DPPH scavenging activity and also DNA nuclease activity. The antimicrobial activity of the new compounds was evaluated by the disc diffusion assay. Effective microbial cell viability inhibition was observed with phthalocyanine macromolecules. The photodynamic antimicrobial therapy of the phthalocyanines showed 100% bacterial inhibition when compared to the control. They also exhibited significant biofilm inhibition activity against S. aureus and P. aeruginosa. These results indicate that new phthalocyanines are promising photodynamic antimicrobial therapies for the treatment of infectious diseases.read more
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Biological properties of hexadeca-substituted metal phthalocyanines bearing different functional groups.
TL;DR: In this article , a tetra-substituted phthalonitrile (diethyl 2-(2-chloro-4,5-dicyano-3,6-bis(hexyloxy)phenyl)malonate) bearing three different substituents was synthesized and characterized.
Journal ArticleDOI
The design and Synthesis of Metallophthalocyanine-Gold Nanoparticle Hybrids as Biological Agents
Nazli Farajzadeh,Javaria Aftab,H. Yasemin Yenilmez,Sadin Özdemir,Serpil Gonca,Zehra Altuntaş Bayır +5 more
TL;DR: In this paper , the synthesis of 4-2-(4-ethynyl-N,N-dimethylaniline)pthalonitrile and its peripherally tetra-substituted metal phthalocyanines was presented.
Journal ArticleDOI
Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment
José C. Páez-Franco,Miriam R. Zermeño-Ortega,Carmen Myriam de la O-Contreras,Daniel Canseco-González,Jesús Ricardo Parra-Unda,Alcives Avila-Sorrosa,Raúl G. Enríquez,Juan Manuel Germán-Acacio,David Morales-Morales +8 more
TL;DR: This review discusses the use of fluorinated ligands in the design of metallodrugs that may exhibit potential anticancer activity and suggests two approaches have been developed: one based on theDesign of novel metallo-delivering carriers and the other based on optimizing the structure of the ligands bound to the metal center.
Journal ArticleDOI
Anticancer and biological properties of new axially disubstituted silicon phthalocyanines.
TL;DR: These compounds were screened for cytotoxic and apoptotic effects against a human colon cancer cell line (DLD-1) by performing MTT and Annexin V assays and reveal that they can be utilized for cancer therapy after further investigations.
Journal ArticleDOI
Synthesis of a novel axially substituted silicon phthalocyanine sensitizer for efficient singlet oxygen generation by comparing PDT and SPDT studies
TL;DR: In this paper , a new photosensitizer, naphthoic acid substituted silicon phthalocyanine, is synthesized and characterized by elemental analysis, 1 H-NMR, FT-IR, MALDI-TOF MS and UV-Vis spectral data and its photophysico-chemical properties are investigated.
References
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Photodynamic therapy for cancer
TL;DR: PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.
Journal ArticleDOI
Biofilms: an emergent form of bacterial life.
Hans-Curt Flemming,Jost Wingender,Ulrich Szewzyk,Peter D. Steinberg,Scott A. Rice,Staffan Kjelleberg +5 more
TL;DR: The fundamental role of the biofilm matrix is considered, describing how the characteristic features of biofilms — such as social cooperation, resource capture and enhanced survival of exposure to antimicrobials — all rely on the structural and functional properties of the matrix.
Journal ArticleDOI
Photodynamic therapy - mechanisms, photosensitizers and combinations.
Stanisław Kwiatkowski,Bartosz Knap,Dawid Przystupski,Jolanta Saczko,Ewa Kędzierska,Karolina Knap-Czop,Jolanta Kotlinska,Olga Michel,Krzysztof Kotowski,Julita Kulbacka +9 more
TL;DR: The object of this review is the anticancer application of PDT, its advantages and possible modifications to potentiate its effects, and the use of nanoparticles enables achievement a targeted method which is focused on specific receptors, and, as a result, increases the selectivity of the photodynamic therapy.
Journal ArticleDOI
Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy and beyond
Fatma Vatansever,Wanessa C.M.A. de Melo,Wanessa C.M.A. de Melo,Pinar Avci,Pinar Avci,Daniela Vecchio,Magesh Sadasivam,Magesh Sadasivam,Asheesh Gupta,Asheesh Gupta,Rakkiyappan Chandran,Rakkiyappan Chandran,Mahdi Karimi,Mahdi Karimi,Nivaldo Antonio Parizotto,Rui Yin,Rui Yin,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +19 more
TL;DR: Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered and reactive nitrogen species and related therapeutics, such as acidified nitrite and nitric oxide-releasing nanoparticles are covered.