Novel Xanthone Derivatives Impair Growth and Invasiveness of Colon Cancer Cells In Vitro
Jakub Rech,Daniel Sypniewski,Dorota Żelaszczyk,Natalia Szkaradek,Wojciech Rogóż,Anna M. Waszkielewicz,Henryk Marona,Ilona Bednarek +7 more
- Vol. 11, Iss: 10, pp 1480
TLDR
In this paper, the influence of four xanthone derivatives based on a naturally occurring Xanthone skeleton on the invasiveness of colorectal cancer cells in vitro was investigated.Abstract:
Natural xanthones are a large group of compounds from which promising anticancer properties could be further developed by chemical modifications. This study aimed to investigate the influence of four novel xanthone derivatives based on a naturally occurring xanthone skeleton on the invasiveness of colon cancer cells in vitro. First, the concentrations required to inhibit growth of three colorectal cancer cell lines to 50% (GI50) of all the studied compounds, as well as the natural xanthones used as a reference (gambogic acid and α-mangostin), have been established (MTS reduction test). Next, the assays determining several aspects of the GI25 xanthones influence on colorectal cancer cells, including cytotoxicity, migration and invasion potential, interaction with extracellular matrix and endothelial cells, as well as expression of selected invasiveness related genes have been performed. Our results demonstrate that these novel xanthone derivatives impair colorectal cancer proliferation, motility, adhesion to extracellular matrix and to endothelial cells, and also induce apoptosis and cell death. Moreover, their activity is comparable to cisplatin and 5-fluorouracil, used as reference compounds. Conducted research indicates our compounds for further research and development as novel drugs in colorectal cancer treatment.read more
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Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of Rollinia dolabripetala leaves
Mateus Gandra Campos,Tânia Oliveira,Abelardo Júnior,Marcelo Augusto Filardi,Cristiano T. de Souza,M. J. C. Costa,Liovando Marciano da Costa +6 more
TL;DR: In this article , the authors investigated the antioxidant, anti-melanoma, antistaphylococcal and anti-streptococcal potential of hydroalcoholic extracts of Rollinia dolabripetala leaves and of 1.7 -dihydroxyxanthone and xanthone phytocompounds.
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Xanthone Derivatives in the Fight against Glioblastoma and Other Cancers
TL;DR: In this article , a tabular summary of the literature results of antineoplastic activity (e.g., IC50 values) for xanthone derivatives in various types of in vitro viability assays is presented.
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Bioactive Molecules: Structures, Functions, and Potential Uses for Cancer Prevention and Targeted Therapies
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of the £10,000 ($13,000) target to provide real-time information on how to effectively and effectively diagnose and treat cancer in the clinic.
Journal ArticleDOI
Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids
Sara Vieira,Joana Margarida Soares Araújo,Virgínia M.F. Gonçalves,Carla Fernandes,Madalena Pinto,Helena Ferreira,Nuno M. Neves,Maria Elizabeth Tiritan +7 more
TL;DR: In this paper , the synthesis of a library of CDXs is described, by coupling a carboxyxanthone with both enantiomers of proteinogenic amino esters as chiral building blocks following the chiral pool strategy.
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