Tissue invasion and metastasis: Molecular, biological and clinical perspectives.
Wen Guo Jiang,Andrew James Sanders,Masaru Katoh,H. Ungefroren,Frank Gieseler,Mark E. Prince,Sarah K. Thompson,Massimo Zollo,Daniela Spano,P. Dhawan,Daniel Sliva,Pochi R. Subbarayan,Malancha Sarkar,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Lin Ye,William G. Helferich,Xujuan Yang,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Asfar S. Azmi,W N Keith,Alan Bilsland,Dipita Bhakta,Dorota Halicka,Somaira Nowsheen,Francesco Pantano,Daniele Santini +35 more
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This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEBAbout:
This article is published in Seminars in Cancer Biology.The article was published on 2015-12-01 and is currently open access. It has received 387 citations till now. The article focuses on the topics: Metastasis & Cancer.read more
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Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.
Jawad Abed,Johanna E. M. Emgård,Gideon Zamir,Mouhammad Faroja,Gideon Almogy,Amalie Grenov,Asaf Sol,Ronit Naor,Eli Pikarsky,Karine Atlan,Anna Mellul,Stella Chaushu,Abigail L. Manson,Ashlee M. Earl,Nora Ou,Caitlin A. Brennan,Wendy S. Garrett,Gilad Bachrach +17 more
TL;DR: A host polysaccharide and fusobacterial lectin that explicates fusObacteria abundance in CRC is identified and targeting F. nucleatum Fap2 or host epithelial Gal-GalNAc may reduce fusOBacteria potentiation of CRC.
Journal ArticleDOI
Bisphenol A (BPA) and cell signaling pathways.
Masaharu Murata,Jeong Hun Kang +1 more
TL;DR: This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity- related cell signaling pathway, inflammatory or immune response-related Cell signaling pathways; and brain and nervous system-relatedcell signaling pathways.
Journal ArticleDOI
Recent advances in magnetic fluid hyperthermia for cancer therapy
TL;DR: The fundamental principles of magnetic hyperthermia, basics of magnetism, synthetic methods and nanoparticle surface chemistry needed to design and develop an ideal magnetic nanoparticle heat mediator suitable for clinical translation in cancer therapy are addressed.
Book ChapterDOI
Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair.
TL;DR: The functions of MMPs and their inhibitors in bone cells, during bone remodeling, pathological bone resorption (osteoporosis and bone metastasis), bone repair/regeneration, and emergent roles in bone bioengineering are discussed.
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Mutant p53 in cancer therapy-the barrier or the path.
Xiang Zhou,Qian Hao,Hua Lu +2 more
TL;DR: Some recent progresses in better understanding of the role of Mutant p53 GOF in chemoresistance and the underlying mechanisms are reviewed, and the pros and cons of targeting mutant p53 for the development of anti-cancer therapies are discussed.
References
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