E
Elena Niccolai
Researcher at University of Florence
Publications - 76
Citations - 4178
Elena Niccolai is an academic researcher from University of Florence. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 24, co-authored 62 publications receiving 3090 citations.
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Journal ArticleDOI
Broad targeting of resistance to apoptosis in cancer.
Ramzi M. Mohammad,Irfana Muqbil,Leroy Lowe,Clement G. Yedjou,Hsue-Yin Hsu,Liang Tzung Lin,Markus D. Siegelin,Carmela Fimognari,Nagi B. Kumar,Q. Ping Dou,Huanjie Yang,Abbas Samadi,Gian Luigi Russo,Carmela Spagnuolo,Swapan K. Ray,Mrinmay Chakrabarti,James D. Morre,Helen M. Coley,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,William G. Helferich,Xujuan Yang,Chandra S. Boosani,Gunjan Guha,Dipita Bhakta,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Sulma I. Mohammed,W. Nicol Keith,Alan Bilsland,Dorota Halicka,Somaira Nowsheen,Asfar S. Azmi +38 more
TL;DR: This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer.
Journal ArticleDOI
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Mark A. Feitelson,Alla Arzumanyan,Rob J. Kulathinal,Stacy W. Blain,Randall F. Holcombe,Jamal Mahajna,Maria Marino,María L. Martínez-Chantar,Roman Nawroth,Isidro Sánchez-García,Dipali Sharma,Neeraj K. Saxena,Neetu Singh,Panagiotis J. Vlachostergios,Shanchun Guo,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Alan Bilsland,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Sulma I. Mohammed,Asfar S. Azmi,Dipita Bhakta,Dorota Halicka,W. Nicol Keith,Somaira Nowsheen +33 more
TL;DR: Natural compounds found to inhibit one or more pathways that contribute to proliferation have been found and will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.
Journal ArticleDOI
Broad targeting of angiogenesis for cancer prevention and therapy
Zongwei Wang,Charlotta Dabrosin,Xin Yin,Mark M. Fuster,Alexandra Arreola,W. Kimryn Rathmell,Daniele Generali,Ganji Purnachandra Nagaraju,Bassel F. El-Rayes,Domenico Ribatti,Yi Charlie Chen,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Somaira Nowsheen,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Bill Helferich,Xujuan Yang,Gunjan Guha,Dipita Bhakta,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Dorota Halicka,Sulma I. Mohammed,Asfar S. Azmi,Alan Bilsland,W. Nicol Keith,Lasse Jensen,Lasse Jensen +32 more
TL;DR: 10 important aspects of tumor angiogenesis and the pathological tumor vasculature which would be well suited as targets for anti-angiogenic therapy are identified and 10 plant-derived compounds could be combined to constitute a broader acting and more effective inhibitory cocktail at doses that would not be likely to cause excessive toxicity.
Journal ArticleDOI
Tissue invasion and metastasis: Molecular, biological and clinical perspectives.
Wen Guo Jiang,Andrew James Sanders,Masaru Katoh,H. Ungefroren,Frank Gieseler,Mark E. Prince,Sarah K. Thompson,Massimo Zollo,Daniela Spano,P. Dhawan,Daniel Sliva,Pochi R. Subbarayan,Malancha Sarkar,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Lin Ye,William G. Helferich,Xujuan Yang,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Asfar S. Azmi,W N Keith,Alan Bilsland,Dipita Bhakta,Dorota Halicka,Somaira Nowsheen,Francesco Pantano,Daniele Santini +35 more
TL;DR: This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB
Journal ArticleDOI
Cancer prevention and therapy through the modulation of the tumor microenvironment.
Stephanie C. Casey,Amedeo Amedei,Katia Aquilano,Asfar S. Azmi,Fabian Benencia,Dipita Bhakta,Alan Bilsland,Chandra S. Boosani,Sophie Chen,Maria Rosa Ciriolo,Sarah Crawford,Hiromasa Fujii,Alexandros G. Georgakilas,Gunjan Guha,Dorota Halicka,William G. Helferich,Petr Heneberg,Kanya Honoki,W. Nicol Keith,Sid P. Kerkar,Sulma I. Mohammed,Elena Niccolai,Somaira Nowsheen,H.P. Vasantha Rupasinghe,Abbas Samadi,Neetu Singh,Wamidh H. Talib,Vasundara Venkateswaran,Richard L. Whelan,Xujuan Yang,Dean W. Felsher +30 more
TL;DR: Inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted.