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Obovatol and Obovatal, Novel Biphenyl Ether Lignans from the Leaves of Magnolia obovata THUNB.

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TLDR
Two new biphenyl ether lignans were isolated from the leaves of Magnolia obovata THUNB and showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans, but was less active than magnolol (5) and honokiol (6).
Abstract
Two new biphenyl ether lignans, named obovatol (1) and obovatal (2) were isolated from the leaves of Magnolia obovata THUNB. (Magnoliaceae) and their chemical structures were determined to be 4', 5-diallyl-2, 3-dihydroxybiphenyl ether and 3, 4-dihydroxy-5-(pallylphenoxy) cinnamic aldehyde by means of chemical and spectral studies. The former substance showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans, but was less active than magnolol (5) and honokiol (6).

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Journal ArticleDOI

Therapeutic applications of compounds in the Magnolia family

TL;DR: The aim of this study was to review a variety of experimental and clinical reports and, describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of Magnolia and/or its constituents.
Journal ArticleDOI

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease.

TL;DR: Oxidative stress is a cardinal hallmark of the disease and has been considered as therapeutic target for AD treatment, and antioxidant neuroprotective effects and therapeutic potential for AD of selected natural polyphenolic compounds are described.
Journal ArticleDOI

Two antiplatelet agents from Magnolia officinalis.

TL;DR: It is concluded that the antiplatelet effect of magnolol and honokiol is due to an inhibitory effect on thromboxane formation and also an inhibition of intracellular calcium mobilization.
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Inhibitors of microglial neurotoxicity: focus on natural products.

TL;DR: Future works should focus on the discovery of novel drug targets that specifically mediate microglial neurotoxicity rather than neuroprotection, and development of new drugs based on these targets may require a better understanding of microglia biology and neuroinflammation at the molecular, cellular, and systems levels.
Journal ArticleDOI

Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages.

TL;DR: Active constituents of methanolic extract of Magnolia obovata showed weak inhibition for inducible NO synthase (iNOS) enzyme activity, but potent inhibition of iNOS induction and activation of nuclear factor-kappaB.
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