Journal ArticleDOI
One-Pot Synthesis of Rotationally Restricted, Conjugatable, BODIPY Derivatives from Phthalides.
Mayca del Rio,Fernando Lobo,J. Cristobal Lopez,Ainhoa Oliden,Jorge Bañuelos,Iñigo López-Arbeloa,Inmaculada García-Moreno,Ana M. Gómez +7 more
TLDR
O-Ethylation of phthalides with Meerwein's reagent followed by reaction of the ensuing salts with pyrrole, results in the formation of 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with borontrifluoride etherate.Abstract:
O-Ethylation of phthalides with Meerwein’s reagent followed by reaction of the ensuing salts with pyrrole, results in the formation of 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with borontrifluoride etherate, an overall process that can be carried out in a one-pot operation.read more
Citations
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Journal ArticleDOI
Mitochondria-Targeting Selenophene-Modified BODIPY-Based Photosensitizers for the Treatment of Hypoxic Cancer Cells
Osman Karaman,Toghrul Almammadov,M. Emre Gedik,Gurcan Gunaydin,Safacan Kolemen,Gorkem Gunbas +5 more
TL;DR: Two red‐absorbing, water‐soluble and mitochondria (MT)‐targeting selenophene‐substituted BODIPY‐based photosensitizers were realized, and their potential as photodynamic therapy (PDT) agents were evaluated.
Journal ArticleDOI
Polybrominated BOPHY Dyes: Synthesis, Reactivity and Properties
TL;DR: The positions in which bromines or substituents are attached modulate the photophysical properties of the resulting BOPHY dyes, and most of them showed strong absorbance and bright fluorescence with maximum wavelengths centered at between the range of 430 and 660 nm.
Journal ArticleDOI
Prevalent Bioimaging Scaffolds: Synthesis, Photophysical Properties and Applications
Journal ArticleDOI
Current Advances in the Synthesis of Valuable Dipyrromethane Scaffolds: Classic and New Methods.
TL;DR: This review presents the most recent developments on the synthesis of dipyrromethanes, covering classical synthetic strategies, using acid catalyzed condensation of pyrroles and aldehydes or ketones, and recent breakthroughs which allow the synthesisation of these type of heterocycles with new substitution patterns.
Journal ArticleDOI
Syntheses of o-iodobenzyl alcohols‒BODIPY structures as potential precursors of bimodal tags for positron emission tomography and optical imaging
TL;DR: Aiming the faster development from bench to bedside of new potential tracers, multimodal tracers for positron emission tomography (PET) and optical imaging (OI) have emerged as a very promising tool.
References
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Journal ArticleDOI
BODIPY dyes and their derivatives: syntheses and spectroscopic properties.
Aurore Loudet,Kevin Burgess +1 more
Journal ArticleDOI
The Chemistry of Fluorescent Bodipy Dyes: Versatility Unsurpassed
TL;DR: The Bodipy family, first developed as luminescent tags and laser dyes, has become a cornerstone for these new applications and the near future looks extremely bright for "porphyrin's little sister".
Journal ArticleDOI
Fluorescent indicators based on BODIPY
TL;DR: This critical review covers the advances made using the 4-bora-3a,4a-diaza-s-indacene (BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent indicators for pH, metal ions, anions, biomolecules, reactive oxygen species, reactive nitrogen species, redox potential, chemical reactions and various physical phenomena.
Journal ArticleDOI
Structural modification strategies for the rational design of red/NIR region BODIPYs
TL;DR: This review focuses on classifying different types of long wavelength absorbing BODIPY dyes based on the wide range of structural modification methods that have been adopted, and on tabulating their spectral and photophysical properties.
Journal ArticleDOI
BODIPY-based probes for the fluorescence imaging of biomolecules in living cells
TL;DR: Advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade are covered.
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BODIPY dyes and their derivatives: syntheses and spectroscopic properties.
Aurore Loudet,Kevin Burgess +1 more