Journal ArticleDOI
Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantation.
Nina Khanna,Ingrid Steffen,Jan Dirk Studt,A. Schreiber,Thomas Lehmann,Maja Weisser,Ursula Flückiger,Alois Gratwohl,Jörg Halter,Hans H. Hirsch,Hans H. Hirsch +10 more
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TLDR
This data indicates that hematopoietic stem cell transplantation patients after HSCs are at high risk of developing influenza, and the diagnostic methods and antiviral treatment for this disease have scarcely been investigated.Abstract:
Influenza can cause significant morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT)read more
Citations
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Journal ArticleDOI
Influenza in Immunosuppressed Populations: A Review of Infection Frequency, Morbidity, Mortality, and Vaccine Responses
TL;DR: Available data suggest that most immunosuppressed populations are indeed at higher risk of influenza-associated complications, have a general trend toward impaired humoral vaccine responses (although these data are mixed), and can be safely vaccinated--although longitudinal data are largely lacking.
Journal ArticleDOI
Antivirals and resistance: influenza virus.
TL;DR: This paper will review the currently approved and investigational antiviral agents and the mechanisms of resistance that impact their activity and identify several classes of antivirals and immune modulators under investigation.
Journal ArticleDOI
Guidance on Novel Influenza A/H1N1 in Solid Organ Transplant Recipients†
Deepali Kumar,Michele I. Morris,Camille N. Kotton,Staci A. Fischer,Marian G. Michaels,Upton Allen,Emily A. Blumberg,Michael Green,Atul Humar,Michael G. Ison +9 more
TL;DR: Current guidance for H1N1 as it relates to solid organ transplantation includes discussion around clinical presentation, diagnosis, therapy and prevention specifically addressing areas such as chemoprophylaxis, immunization and donor‐derived infection.
Journal ArticleDOI
A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients.
Deepali Kumar,Victor H Ferreira,Emily A. Blumberg,Fernanda P. Silveira,Elisa Cordero,Pilar Pérez-Romero,Teresa Aydillo,Lara Danziger-Isakov,Ajit P. Limaye,Jordi Carratalà,Patricia Muñoz,Miguel Montejo,Francisco López-Medrano,María Carmen Fariñas,Joan Gavaldà,Asunción Moreno,Marilyn E. Levi,Jesús Fortún,Julián Torre-Cisneros,Janet A. Englund,Yoichiro Natori,Shahid Husain,Gail E. Reid,Tanvi Sharma,Atul Humar +24 more
TL;DR: Annual influenza vaccination and early antiviral therapy are associated with a significant reduction in influenza-associated morbidity, and should be emphasized as strategies to improve outcomes of transplant recipients.
Journal ArticleDOI
RNA respiratory viral infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
TL;DR: These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of RNA respiratory viral infections in the pre‐ and post‐transplant period.
References
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Journal ArticleDOI
Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations.
TL;DR: Oseltamivir treatment of influenza illness reduces LRTCs, antibiotic use, and hospitalization in both healthy and "at-risk" adults.
Journal ArticleDOI
Simultaneous Detection of Influenza Viruses A and B Using Real-Time Quantitative PCR
TL;DR: This method simultaneously detects influenza viruses A and B in specimens of patients with respiratory infections using a TaqMan-based real-time PCR assay, which was found to be more sensitive than the combination of conventional viral culturing and shell vial culturing.
Journal ArticleDOI
Influenza Infections after Hematopoietic Stem Cell Transplantation: Risk Factors, Mortality, and the Effect of Antiviral Therapy
TL;DR: It is suggested that early antiviral therapy with neuraminidase inhibitors may prevent progression to pneumonia and decrease viral shedding, which may prevent both influenza-related death in index patients and nosocomial transmission to others.
Journal ArticleDOI
Respiratory Viral Infections in Adults With Hematologic Malignancies and Human Stem Cell Transplantation Recipients: A Retrospective Study at a Major Cancer Center
Roy F. Chemaly,S. Ghosh,Gerald P. Bodey,Nidhi Rohatgi,Amar Safdar,Michael J. Keating,Richard E. Champlin,Elizabeth A. Aguilera,Jeffrey J. Tarrand,Issam I Raad +9 more
TL;DR: Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients and patients with hematologic malignancies and HSCT recipients should be considered for antiviral therapy of proven efficacy to reduce the risk of tuberculosis and death.
Journal ArticleDOI
Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.
Per Ljungman,Katherine N. Ward,B. N. Crooks,Anne Parker,Rodrigo Martino,Peter J. Shaw,Lorentz Brinch,Mats Brune,R de la Cámara,A. W. Dekker,Karlis Pauksen,Nigel H. Russell,Anthony P. Schwarer,Catherine Cordonnier +13 more
TL;DR: The fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT is supported and lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections.
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Deepali Kumar,Marian G. Michaels,Michele I. Morris,Michael Green,Robin K. Avery,Catherine Liu,Lara Danziger-Isakov,Valentina Stosor,Michele M. Estabrook,Soren Gantt,Kieren A. Marr,Stanley I. Martin,Fernanda P. Silveira,Raymund R. Razonable,Upton Allen,Marilyn E. Levi,G. Marshall Lyon,Lorraine E. Bell,Shirish Huprikar,Gopi Patel,Kevin S. Gregg,Kenneth Pursell,Doug Helmersen,Kathleen G. Julian,Kevin T. Shiley,Bartholomew Bono,Vikas R. Dharnidharka,Gelareh Alavi,Jayant S. Kalpoe,Shmuel Shoham,Gail E. Reid,Atul Humar +31 more