Journal ArticleDOI
Oxidative stress, protein damage and repair in bacteria
TLDR
This Review discusses the current understanding of the reducing systems that enable bacteria to repair oxidatively damaged cysteine and methionine residues in the cytoplasm and in the bacterial cell envelope, and highlights the importance of these repair systems in bacterial physiology and virulence.Abstract:
Oxidative damage can have a devastating effect on the structure and activity of proteins, and may even lead to cell death. The sulfur-containing amino acids cysteine and methionine are particularly susceptible to reactive oxygen species (ROS) and reactive chlorine species (RCS), which can damage proteins. In this Review, we discuss our current understanding of the reducing systems that enable bacteria to repair oxidatively damaged cysteine and methionine residues in the cytoplasm and in the bacterial cell envelope. We highlight the importance of these repair systems in bacterial physiology and virulence, and we discuss several examples of proteins that become activated by oxidation and help bacteria to respond to oxidative stress.read more
Citations
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Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Pathophysiology of Type 2 Diabetes Mellitus.
Unai Galicia-Garcia,Asier Benito-Vicente,Shifa Jebari,Asier Larrea-Sebal,Haziq Siddiqi,Kepa B. Uribe,Helena Ostolaza,César Martín +7 more
TL;DR: This review analyzes the key aspects of type 2 Diabetes Mellitus, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance, and summarizes the data gathered up until now.
Journal ArticleDOI
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.
Subbroto Kumar Saha,Soo Bin Lee,Jihye Won,Hye Yeon Choi,Kyeongseok Kim,Gwang-Mo Yang,Ahmed Abdal Dayem,Ssang-Goo Cho +7 more
TL;DR: An overview of the relationship between nutrition, oxidative stress, and cancer initiation is provided, and the impact of nutrient-mediated regulation of antioxidant capability against cancer therapy is evaluated.
Journal ArticleDOI
Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress
Josh J Jenkins,Judith Mantell,Christopher R. Neal,Ali Gholinia,Paul Verkade,Angela H. Nobbs,Bo Su +6 more
TL;DR: It is shown that nanopillars’ antibacterial activities do not necessarily require bacterial lysis, and may be mediated by oxidative stress induced by deformation of the bacterial cell envelope.
Journal ArticleDOI
The Nano–Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions
TL;DR: The driving force and redox reaction at the nano-bio interface are recognized as the main factors that regulate the functions and toxicities of nanomedicines.
References
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Journal ArticleDOI
Critical Review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (⋅OH/⋅O− in Aqueous Solution
TL;DR: In this article, the rate constants for over 3500 reaction are tabulated, including reaction with molecules, ions and other radicals derived from inorganic and organic solutes, and the corresponding radical anions, ⋅O− and eaq−, have been critically pulse radiolysis, flash photolysis and other methods.
Journal Article
Critical review of rate condtants for reaction of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution
Journal ArticleDOI
The Bacterial Cell Envelope
TL;DR: The bacteria cell envelope is a complex multilayered structure that serves to protect these organisms from their unpredictable and often hostile environment.
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H2O2, a necessary evil for cell signaling
TL;DR: Once considered lethal to cells, reactive oxygen species are now known to be involved in redox signaling pathways that may contribute to normal cell function as well as disease progression.
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Cellular Defenses against Superoxide and Hydrogen Peroxide
TL;DR: Bacteria comprise an exceptionally accessible experimental system that has provided many of the answers to the remaining puzzles in an anaerobic world, and current research seeks to identify these.