Journal ArticleDOI
Oxytocin and autistic disorder: alterations in peptide forms.
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TLDR
The results suggest that children with autistic disorder show alterations in the endocrine OT system, and defects in OT peptide processing in children with autism may be important in the development of this syndrome.About:
This article is published in Biological Psychiatry.The article was published on 2001-10-15. It has received 381 citations till now.read more
Citations
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Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
TL;DR: Oxytocin seems to enhance the buffering effect of social support on stress responsiveness, concur with data from animal research suggesting an important role of oxytocin as an underlying biological mechanism for stress-protective effects of positive social interactions.
Journal ArticleDOI
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Journal ArticleDOI
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
TL;DR: OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
Journal ArticleDOI
Oxytocin improves "mind-reading" in humans.
TL;DR: Oxytocin improves the ability to infer the mental state of others from social cues of the eye region, and might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
Journal ArticleDOI
The Genetics of Autism
TL;DR: Significant evidence is found for multiple interacting genetic factors as the main causative determinants of autism and for interactions between multiple genes cause "idiopathic" autism but that epigenetic factors and exposure to environmental modifiers may contribute to variable expression of autism-related traits.
References
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Society for Neuroscience Abstracts
Gemma A. Calvert,E.T. Bullmore,Michael Brammer,Robert M. Bilder,A.S. David,Susan D. Iversen,Steven T Williams,Thomas W. Crowther +7 more
Journal ArticleDOI
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Nabil G. Seidah,Michel Chrétien +1 more
TL;DR: While PCs are responsible for the processing of neuropeptides, adhesion molecules, receptors, growth factors, cell surface glycoprotein and enzymes, SKI-1 cleaves proproteins that are critical for the control of cholesterol and fatty acid metabolism and for neuronal protection and growth.
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Plasma oxytocin levels in autistic children.
Charlotte Modahl,Lee Anne Green,Deborah Fein,Mariana Morris,Lynn Waterhouse,Carl Feinstein,Harriet Levin +6 more
TL;DR: The data suggest that OT abnormalities may exist in autism, and that more direct investigation of central nervous system OT function is warranted, after making inferences to central OT functioning from peripheral measurement.
Journal ArticleDOI
Oxytocin--a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies.
TL;DR: New studies in rat pups demonstrate that central OT selectively decreases the separation response, an effect which mimics social contact, and demonstrate that physiologic changes in gonadal steroids can alter receptor expression in anatomically discrete target fields and thereby direct responsiveness to endogenous neuropeptide release.