Journal ArticleDOI
Palladium-Catalyzed Intermolecular Aerobic Annulation of o-Alkenylanilines and Alkynes for Quinoline Synthesis.
TLDR
A new approach to construct 2,3-disubstituted quinolines is described via Pd-catalyzed oxidative cyclization of o-vinylanilines and alkynes with molecular oxygen.About:
This article is published in Organic Letters.The article was published on 2016-07-15. It has received 57 citations till now. The article focuses on the topics: Alkyne & Annulation.read more
Citations
More filters
Synthesis of Heterocycles via Pd-Ligand Controlled Cyclization of 2-Chloro-N-(2-vinyl)aniline: Preparation of Carbazoles, Indoles, Dibenzazepines and Acridines
TL;DR: In this paper, the Pd-catalyzed condensation of 2-bromostyrene and 2-chloroaniline derivatives yields stable diphenylamine intermediates, which are selectively converted to five-, six-, or seven-membered heteroaromatics (indoles, carbazoles, acridines, and dibenzazepines).
Journal ArticleDOI
The Modern Face of Synthetic Heterocyclic Chemistry
Chiara Cabrele,Oliver Reiser +1 more
TL;DR: Some recent advances in the construction of heterocycles are discussed, focusing on catalytic methodology, which has contributed in a major way to developments of green and sustainable chemistry.
Journal ArticleDOI
Visible-light-induced multicomponent cascade cycloaddition involving N-propargyl aromatic amines, diaryliodonium salts and sulfur dioxide: rapid access to 3-arylsulfonylquinolines
Deli Sun,Kun Yin,Ronghua Zhang +2 more
TL;DR: A visible-light-induced, Eosin Y catalyzed three-component synthesis of 3-arylsulfonylquinoline derivatives through N-propargyl aromatic amines, diaryliodonium salts and sulfur dioxide has been discovered.
Journal ArticleDOI
Advances in Palladium-Catalyzed Cascade Cyclizations
Jasper Biemolt,Eelco Ruijter +1 more
TL;DR: Palladium-catalyzed cross-coupling reactions, with their well understood multistep catalytic cycles, form a promising basis for the design of cascade reactions as mentioned in this paper.
Journal ArticleDOI
Cascade Reaction of Isatins with 1,1-Enediamines: Synthesis of Multisubstituted Quinoline-4-carboxamides
TL;DR: A one-step methodology for the synthesis of multisubstituted quinoline-4-carboxamides was developed by simply refluxing a mixture of isatins 1 and various kinds of 1,1-enediamines 2-4 in a reaction catalyzed by NH2SO3H.
References
More filters
Journal ArticleDOI
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.
Koen Andries,Peter Verhasselt,Jerome Guillemont,Hinrich W. H. Göhlmann,Jean-Marc Neefs,Hans Winkler,Jef Van Gestel,Philip Timmerman,Min Zhu,Ennis Lee,Peter Williams,Didier de Chaffoy,Emma Huitric,Sven Hoffner,Emmanuelle Cambau,Chantal Truffot-Pernot,Nacer Lounis,Vincent Jarlier +17 more
TL;DR: A diarylquinoline, R207910, is identified that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase.
Journal ArticleDOI
Quinoline, quinazoline and acridone alkaloids
TL;DR: This review covers the isolation, structure determination, synthesis and biological activity of quinoline, quinazoline and acridone alkaloids from plant, microbial and animal sources.
Journal ArticleDOI
Transition-metal-catalyzed addition of heteroatom-hydrogen bonds to alkynes.
Journal ArticleDOI
Gold-catalyzed carbon-heteroatom bond-forming reactions.
TL;DR: Application to Total Synthesis 1699 6.1.
Journal ArticleDOI
Palladium(II)-Catalyzed Alkene Functionalization via Nucleopalladation: Stereochemical Pathways and Enantioselective Catalytic Applications
TL;DR: Enantioselective PdII-catalyzed functionalization of alkenes has experienced considerably less success than have many other classes of enantiOSElective transformations, despite the extensive history of the Wacker process and related oxidation reactions.