Pannexin membrane channels are mechanosensitive conduits for ATP
TLDR
Pannexin 1 channels have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive, Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress.About:
This article is published in FEBS Letters.The article was published on 2004-08-13 and is currently open access. It has received 739 citations till now. The article focuses on the topics: Mechanosensitive channels & Pannexin.read more
Citations
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Local force and geometry sensing regulate cell functions.
Viola Vogel,Michael P. Sheetz +1 more
TL;DR: Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
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Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor
TL;DR: Pannexin‐1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, is identified as this dye‐uptake pathway and signalling through pannexin•1 is required for processing of caspase‐1 and release of mature IL‐1β induced by P2X7 receptor activation.
Journal ArticleDOI
Ischemia opens neuronal gap junction hemichannels.
TL;DR: It is shown that ischemic-like conditions [O2/glucose deprivation (OGD] open hemichannels, or half gap junctions, in neurons, which contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of isChemic neuronal death.
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The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Yi Jen Huang,Yutaka Maruyama,Gennady Dvoryanchikov,Elizabeth Pereira,Nirupa Chaudhari,Stephen D. Roper +5 more
TL;DR: Results provide a mechanism to link intracellular Ca2+ release during taste transduction to secretion of afferent transmitter, ATP, from receptor cells and indicate a route for cell–cell communication and signal processing within the taste bud.
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Expression and functions of neuronal gap junctions
TL;DR: The roles of connexin and pannexin genes in the formation of neuronal gap junctions are discussed, and recent functional analyses of electrical synapses that became possible through the characterization of mouse mutants that show targeted defects in con Nexin genes are evaluated.
References
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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
TL;DR: The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches.
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Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle.
F. Guharay,Frederick Sachs +1 more
TL;DR: The membrane of tissue‐cultured chick pectoral muscle contains an ionic channel which is activated by membrane stretch, and appears to gather force from a large area of membrane, probably by a cytochalasin‐resistant cytoskeletal network.
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Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels.
TL;DR: Release of ATP through connexin hemichannel activator quinine represents a novel signaling pathway for intercellular communication in astrocytes and other non-excitable cells.
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Connexins regulate calcium signaling by controlling ATP release.
Maria Luisa Cotrina,Jane H.-C. Lin,A. Alves-Rodrigues,Shujun Liu,Jiang Li,H. Azmi-Ghadimi,Jian Kang,Christian C. Naus,M. Nedergaard +8 more
TL;DR: Observations suggest that cell-to-cell signaling associated with connexin expression results from enhanced ATP release and not, as previously believed, from an increase in intercellular coupling.
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Pannexins, a family of gap junction proteins expressed in brain
TL;DR: It is shown that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS and indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.