Pasteurella multocida: from Zoonosis to Cellular Microbiology
Brenda A. Wilson,Mengfei Ho +1 more
TLDR
Recent comparative genomics and molecular pathogenesis studies that have advanced the understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections are reviewed.Abstract:
In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae, Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.read more
Citations
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Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites
TL;DR: The organism possesses virulence attributes of catalase and sialidase production, gliding motility, cytotoxin production, and resistance to killing by serum complement due to its unique lipopolysaccharide.
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Bat–man disease transmission: zoonotic pathogens from wildlife reservoirs to human populations
TL;DR: The purpose of this article is to supply an overview on the main pathogens isolated from bats that have the potential to cause disease in humans.
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Animals in healthcare facilities: recommendations to minimize potential risks.
Rekha Murthy,Gonzalo Bearman,Sherrill Brown,Kristina A. Bryant,Raymond Chinn,Angela L. Hewlett,B. Glenn George,Ellie J. C. Goldstein,Galit Holzmann-Pazgal,Mark E. Rupp,Timothy L. Wiemken,J. Scott Weese,David J. Weber +12 more
TL;DR: General guidance is provided to the medical community regarding the management of animals in healthcare (AHC) and the use of standard infection prevention and control measures to prevent animal-to-human transmission in healthcare settings is provided.
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Clinical Features and Outcomes of Pasteurella multocida Infection
TL;DR: P multocida infections not associated with an animal bite were often associated with bacteremia, severe comorbidity(ies), immune-incompetent states, the need for ICU management, and were associated with substantial mortality.
Journal ArticleDOI
Emerging and Re-Emerging Zoonoses of Dogs and Cats.
TL;DR: Dogs and cats have been sharing the authors' environment for a long time and as pets they bring major psychological well-being to their modern urbanized society, however, they still can be a source of human infection by various pathogens, including viruses, bacteria, parasites, and fungi.
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