Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma.
Rainer Haas,R. Möhle,Stefan Frühauf,Hartmut Goldschmidt,B. Witt,Michael Flentje,Michael Wannenmacher,Werner Hunstein +7 more
Reads0
Chats0
TLDR
If autografting with PBPCs in malignant lymphoma with poor prognosis is being considered, mobilization and harvesting should be planned early after initial diagnosis to avoid exhaustion of hematopoiesis by cumulative toxicity.About:
This article is published in Blood.The article was published on 1994-06-15 and is currently open access. It has received 513 citations till now. The article focuses on the topics: Filgrastim & Leukapheresis.read more
Citations
More filters
Journal ArticleDOI
The Biology and Clinical Uses of Blood Stem Cells
TL;DR: It seems more than ever likely that blood-derived stem cells will replace marrow for many indications, according to recent data from the International Bone Marrow Transplant Registry (IBMTR).
Journal ArticleDOI
Factors that influence collection and engraftment of autologous peripheral-blood stem cells.
William I. Bensinger,F R Appelbaum,S Rowley,R Storb,Jean E. Sanders,K Lilleby,Ted Gooley,Taner Demirer,Kathy Schiffman,C. H. Weaver +9 more
TL;DR: CD34 cell dose is an important predictor of engraftment kinetics after PBSC transplant, regardless of disease or mobilization technique, and the use of postinfusion CSF improves neutrophil recovery, but at low CD34 doses can delay platelet recovery.
Journal ArticleDOI
Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients
Guido Tricot,Sundar Jagannath,David H. Vesole,Jean Nelson,Sharon Tindle,Langdon Miller,Bruce Cheson,John Crowley,Bart Barlogie +8 more
TL;DR: In the absence of CD34 measurements, fast recovery of platelets to greater than 50 x 10(9)/L within 14 days after high-dose cyclophosphamide and < or = 12 months of prior chemotherapy were the best predictors of early engraftment.
Journal ArticleDOI
Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments.
Madhu Mazumdar,Jill R. Glassman +1 more
TL;DR: The combined use of these methods is recommended, and demonstrated in the context of two cancer-related examples which highlight a variety of the issues involved in the categorization of prognostic variables.
Journal ArticleDOI
Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation.
Iskra Pusic,Shi Yuan Jiang,Scott Landua,Geoffrey L. Uy,Michael P. Rettig,Amanda F. Cashen,Peter Westervelt,Ravi Vij,Camille N. Abboud,Keith Stockerl-Goldstein,Diane S. Sempek,Angela Smith,John F. DiPersio +12 more
TL;DR: There is a need for more effective first-line mobilization agents for autologous stem cell mobilization practices, as patients who fail initial mobilization are more likely to fail remobilization.
References
More filters
Journal Article
Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.
TL;DR: It is shown that My-10 is expressed specifically on immature normal human marrow cells, including hematopoietic progenitor cells, as well as by leukemic marrow cells from a subpopulation of patients.
Journal ArticleDOI
Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy
William P. Sheridan,Richard M. Fox,C G Begley,Darryl W. Maher,Katherine M McGrath,Christopher A. Juttner,L. Bik To,Jeff Szer,G. Mostyn +8 more
TL;DR: The ability of filgrastim to mobilise peripheral-blood progenitor cells and assess their efficacy when infused after chemotherapy on recovery of neutrophil and platelet counts was studied in this article.
Journal ArticleDOI
Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation
Alessandro M. Gianni,Marco Bregni,AngelikaC. Stern,Salvatore Siena,Corrado Tarella,Alessandro Pileri,Gianni Bonadonna +6 more
TL;DR: The rapid haematological recovery made possible by this approach promises to increase the therapeutic index of high-dose chemoradiotherapy regimens and to widen their role as treatment for chemoradiosensitive tumours.
Journal ArticleDOI
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients
TL;DR: The absolute number of circulating progenitor cells of granulocyte-macrophage, erythroid, and megakaryocyte lineages showed a dose-related increase up to 100-fold after four days of treatment with rG-CSF and often remained elevated two days after the cessation of therapy and in most patients was slightly decreased.
Journal ArticleDOI
Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients
Salvatore Siena,Marco Bregni,Bruno Brando,N. Belli,Fernando Ravagnani,Lorenza Gandola,A. C. Stern,Peter M. Lansdorp,Gianni Bonadonna,Alessandro M. Gianni +9 more
TL;DR: The data presented in this article favor clinical use of the CD34/CD33 flow cytometry assay to guide harvesting of circulating hematopoietic progenitors for autologous transplantation and contribute to better understanding of the role played by circulating hepatopoiety progenitor cell subsets in marrow recovery after myeloablative cancer therapy.