The Biology and Clinical Uses of Blood Stem Cells
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TLDR
It seems more than ever likely that blood-derived stem cells will replace marrow for many indications, according to recent data from the International Bone Marrow Transplant Registry (IBMTR).About:
This article is published in Blood.The article was published on 1997-04-01 and is currently open access. It has received 725 citations till now. The article focuses on the topics: Bone marrow & Hematopoietic stem cell transplantation.read more
Citations
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Journal ArticleDOI
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Isabelle Petit,Martine Szyper-Kravitz,Arnon Nagler,Meir Lahav,Amnon Peled,Liliana Habler,Tanya Ponomaryov,Russell S. Taichman,Fernando Arenzana-Seisdedos,Nobutaka Fujii,Judith Sandbank,Dov Zipori,Tsvee Lapidot +12 more
TL;DR: It is suggested that manipulation of SDF-1–CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation.
Journal ArticleDOI
Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells.
Tsvee Lapidot,Isabelle Petit +1 more
TL;DR: In this paper, a role for cytokines such as G-CSF and SCF, and adhesion molecules such as VLA-4 and P/E selectins, was determined for stem cell mobilization.
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Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.
TL;DR: It is reported that mobilization of HPCs by GCSF coincides in vivo with the cleavage of the N-terminus of the chemokine receptor CXCR4 on H PCs resident in the BM and mobilized into the PB.
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The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
Amnon Peled,Orit Kollet,Tanya Ponomaryov,Isabelle Petit,Suzanna Franitza,Valentin Grabovsky,Michal Magid Slav,Arnon Nagler,Ofer Lider,Ronen Alon,Dov Zipori,Tsvee Lapidot +11 more
TL;DR: It is demonstrated that repopulating human stem cells functionally express LFA-1, VLA-4, andVLA-5, and this study implies a novel approach to further advance clinical transplantation.
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A newly discovered class of human hematopoietic cells with SCID-repopulating activity
TL;DR: A newly discovered human repopulating cell is identified that initiates multilineage hematopoiesis in NOD/SCID mice and demonstrates complexity of the organization of the human stem- cell compartment and has important implications for clinical applications involving stem-cell transplantation.
References
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Graft-Versus-Leukemia Effect of Donor Lymphocyte Transfusions in Marrow Grafted Patients
Hans-Jochem Kolb,A Schattenberg,JM Goldman,B Hertenstein,N Jacobsen,W Arcese,P Ljungman,A Ferrant,L Verdonck,D Niederwieser +9 more
TL;DR: Donor lymphocyte transfusions exert strong effects against myeloid forms of leukemia and induce durable remissions in CML.
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Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
Elizabeth A. Walter,Phil Greenberg,Mark J. Gilbert,R. J. Finch,Kathe S. Watanabe,Thomas Ed,Stanley R. Riddell +6 more
TL;DR: The transfer of CMV-specific clones of CD8+ T cells derived from the bone marrow donor is a safe and effective way to reconstitute cellular immunity against CMV after allogeneic marrow transplantation.
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The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering.
TL;DR: The four-parameter flow methodology adopted by ISHAGE for validation in a multicenter study in North America is described and its utility on a variety of flow cytometers in clinical laboratories and its reproducibility between transplant centers are established.
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Gene-marking to trace origin of relapse after autologous bone-marrow transplantation
Malcolm K. Brenner,Donna Rill,Robert A. Krance,James N. Ihle,Robert C. Moen,Joseph Mirro,William F. Anderson +6 more
TL;DR: Transfer of the neomycin-resistance gene into bone-marrow cells harvested from children with acute myeloid leukaemia in remission should enable the development of better marrow purging strategies.
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Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells.
TL;DR: Direct evidence is provided for the existence of a single class of progenitors with extensive proliferative capacity in human BM and an experimental approach for their purification, manipulation, and further characterization is provided.
Related Papers (5)
Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells.
Tsvee Lapidot,Isabelle Petit +1 more