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Journal ArticleDOI

Patient-ventilator asynchrony during assisted mechanical ventilation

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TLDR
One-fourth of patients exhibit a high incidence of asynchrony during assisted ventilation, which is associated with a prolonged duration of mechanical ventilation and with excessive levels of ventilatory support.
Abstract
Objective The incidence, pathophysiology, and consequences of patient-ventilator asynchrony are poorly known. We assessed the incidence of patient-ventilator asynchrony during assisted mechanical ventilation and we identified associated factors.

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Citations
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Journal ArticleDOI

Ineffective triggering predicts increased duration of mechanical ventilation

TL;DR: To determine whether high rates of ineffective triggering within the first 24 hrs of mechanical ventilation are associated with longer MV duration and shorter ventilator-free survival, a prospective cohort study at an academic medic hospital is conducted.
Journal ArticleDOI

Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation

TL;DR: Markedly reducing pressure support or inspiratory duration to reach a tidal volume of about 6 ml/kg predicted body weight eliminated ineffective triggering in two-thirds of patients with weaning difficulties and a high percentage of ineffective efforts without inducing excessive work of breathing or modifying patient respiratory rate.
Journal ArticleDOI

Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure.

TL;DR: Compared to PSV, NAVA averted the risk of over-assistance, avoided patient–ventilator asynchrony, and improved patient– ventilator interaction.
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Neurally adjusted ventilatory assist improves patient–ventilator interaction

TL;DR: Compared with standard PS, NAVA can improve patient–ventilator synchrony in intubated spontaneously breathing intensive care patients and further studies should aim to determine the clinical impact of this improved synchrony.
Journal ArticleDOI

Fifty Years of Research in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management.

TL;DR: Accumulating evidence indicates that spontaneous breathing in mechanical ventilation may cause—or worsen—acute lung injury, especially if acute respiratory distress syndrome is severe and spontaneous effort is vigorous.
References
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Journal ArticleDOI

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.

TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
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A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

J R Le Gall, +2 more
- 22 Dec 1993 - 
TL;DR: The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
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Inspiratory Pressure Support Prevents Diaphragmatic Fatigue during Weaning from Mechanical Ventilation

TL;DR: Pressure support ventilation can assist spontaneous breathing and avoid diaphragmatic fatigue in patients demonstrating difficulties in weaning from the ventilator and clinical monitoring of sternocleidomastoid muscle activity allows the required level of pressure support to be determined to prevent fatigue.
Journal ArticleDOI

Ventilator-induced Diaphragmatic Dysfunction

TL;DR: This Critical Care Perspective defines the phenomenon, henceforth referred to as ventilatorinduced diaphragmatic dysfunction (VIDD), as a loss of diaphRAGmatic force-generating capacity that is specifically related to the use of mechanical ventilation.
Journal ArticleDOI

Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction

TL;DR: Low levels of PEEP may improve lung mechanics and reduce the effort required of mechanically ventilated patients with severe airflow obstruction, without substantially increasing the hazards of hyperinflation.
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