Pediatric Acute Liver Failure Due to Type 2 Autoimmune Hepatitis Associated With SARS-CoV-2 Infection: A Case Report
TLDR
In this article , a 3-year-old previously healthy female developed acute liver failure secondary to type 2 autoimmune hepatitis preceded by mild infection with SARS-CoV-2.Abstract:
Although elevated liver enzymes are common in hospitalized children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, pediatric acute liver failure is an uncommon manifestation of COVID-19 disease. We describe the case of a 3-year-old previously healthy female who developed acute liver failure secondary to type 2 autoimmune hepatitis preceded by mild infection with SARS-CoV-2. Testing for viral hepatitis was negative, and the patient did not meet diagnostic criteria for multisystem inflammatory disease in children (MIS-C). A liver biopsy showed acute submassive hepatocyte necrosis with brisk CD3+ T lymphocyte infiltration and no evidence of fibrosis or chronic liver disease. Treatment with high-dose methylprednisolone resulted in rapid normalization of alanine aminotransferase (ALT), aspartate aminotransferase (AST), international normalized ratio (INR), and ammonia levels, and liver transplantation was avoided. This case highlights a possible association between SARS-CoV-2 infection and subsequent development of autoimmune liver disease presenting with acute liver failure. read more
Citations
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High population burden of Omicron variant (B.1.1.529) is associated with the emergence of severe hepatitis of unknown etiology in children
TL;DR: In this article , the authors explored a potential country-based ecological link between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.529) infection and an apparent current global outbreak of severe hepatitis of unknown etiology among children.
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Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak
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[The investigation on the acute, severe hepatitis of unknown origin in children].
Ke Yao,Qinghong Meng,Dan Yu +2 more
TL;DR: Wang et al. as discussed by the authors systematically sorted out the reports and studies on child acute hepatitis of unknown origin, aiming to attract the attention of pediatric clinicians in China, raise awareness and vigilance, and calmly prepare for possible abnormal situations.
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Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?
TL;DR: A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2 as discussed by the authors .
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Hepatitis of unknown etiology in children: What we know and what we can do?
Mingyu Zhu,Li Ern Chen +1 more
TL;DR: This review aims to summarize current research progress and put forward some suggestions on the etiology of acute hepatitis of unknown etiology in children and Adenovirus infection seems to be an important factor.
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