Pegylated Interferon-α for Treating Chronic Hepatitis E Virus Infection after Liver Transplantation
Nassim Kamar,Lionel Rostaing,Florence Abravanel,Cyril Garrouste,Laure Esposito,Isabelle Cardeau-Desangles,Jean Michel Mansuy,Janick Selves,Jean-Marie Péron,Philippe Otal,Fabrice Muscari,Jacques Izopet +11 more
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TLDR
This study assessed the effect of a 3-month course of pegylated interferon-alpha-2a (Peg-IFN-alpha -2a) in 3 liver transplant patients with chronic active hepatitis E.Abstract:
This study assessed the effect of a 3-month course of pegylated interferon-alpha-2a (Peg-IFN-alpha-2a) in 3 liver transplant patients with chronic active hepatitis E. A virological response was sustained for 6 and 5 months in 2 patients after Peg-IFN-alpha-2a therapy was completed. A relapse was observed in the third patient.read more
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Journal ArticleDOI
Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants.
Nassim Kamar,Nassim Kamar,Cyril Garrouste,Elizabeth B. Haagsma,Valérie Garrigue,Sven Pischke,Cecile Chauvet,Jérôme Dumortier,Amelie Cannesson,Elisabeth Cassuto-Viguier,Eric Thervet,Filomena Conti,Pascal Lebray,Harry R. Dalton,Robert N. Santella,Nada Kanaan,Marie Essig,Christiane Mousson,Sylvie Radenne,Anne Marie Roque-Afonso,Jacques Izopet,Jacques Izopet,Lionel Rostaing,Lionel Rostaing +23 more
TL;DR: A retrospective analysis of data from 17 centers from Europe and the United States that described the progression, outcomes, and factors associated with development of chronic HEV infection in recipients of transplanted solid organs found tacrolimus therapy is the main predictive factor for chronic hepatitis.
Journal ArticleDOI
Hepatitis E Virus Infection
Nassim Kamar,Nassim Kamar,Harry R. Dalton,Florence Abravanel,Florence Abravanel,Jacques Izopet,Jacques Izopet +6 more
TL;DR: In this comprehensive review, the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries are summarized.
Journal ArticleDOI
Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients
Nassim Kamar,Jacques Izopet,Simona Tripon,Michael Bismuth,Sophie Hillaire,Jérôme Dumortier,Sylvie Radenne,Audrey Coilly,Valérie Garrigue,Louis d’Alteroche,Matthias Büchler,Lionel Couzi,Pascal Lebray,Sébastien Dharancy,Anne Minello,Maryvonne Hourmant,Anne-Marie Roque-Afonso,Florence Abravanel,Stanislas Pol,Lionel Rostaing,Vincent Mallet +20 more
TL;DR: This retrospective, multicenter study showed that ribavirin as monotherapy may be effective in the treatment of chronic HEV infection; a 3-month course seemed to be an appropriate duration of therapy for most patients.
Journal ArticleDOI
EASL Clinical Practice Guidelines on hepatitis E virus infection
Harry R. Dalton,Nassim Kamar,Sally A. Baylis,Darius Moradpour,Heiner Wedemeyer,Francesco Negro +5 more
TL;DR: These Clinical Practice Guidelines will be on HEV genotype 3 (and 4) and show that locally acquired HEV is now the commonest cause of acute viral hepatitis in many European countries.
Journal ArticleDOI
Hepatitis E virus infection.
Nassim Kamar,Jacques Izopet,Nicole Pavio,Rakesh Aggarwal,Alain B. Labrique,Heiner Wedemeyer,Harry R. Dalton +6 more
TL;DR: HEV infections can be diagnosed by measuring anti-HEV antibodies, HEV RNA or viral capsid antigen in blood or stool and management of immunocompromised individuals involves lowering the dose of immunosuppressive drugs and/or treatment with the antiviral agent ribavirin.
References
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Journal ArticleDOI
An algorithm for the grading of activity in chronic hepatitis C
Pierre Bedossa,Thierry Poynard +1 more
TL;DR: A simple algorithm that generates a single activity score based on basic pathological features in chronic hepatitis C is proposed and tested, showing its accuracy is as high as that obtained using a statistical approach.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
Persistent carriage of hepatitis E virus in patients with HIV infection.
TL;DR: A 48-year-old bisexual white male who was infected with human immunodeficiency virus type 1 (HIV-1) and who had elevated liver enzymes and infection with hepatitis E virus for at least 24 months is described.
Journal ArticleDOI
Chronic hepatitis E with cirrhosis in a kidney-transplant recipient.
TL;DR: The authors report a rapidly progressing case of cirrhosis in a renal-transplant recipient with chronic hepatitis E virus infection.
Journal ArticleDOI
Chronic hepatitis E virus infection in liver transplant recipients.
Elizabeth B. Haagsma,Arie P. van den Berg,Robert J. Porte,Cornelis A. Benne,Harry Vennema,Johan Reimerink,Marion Koopmans +6 more
TL;DR: Chronic HEV infection may develop in immunosuppressed patients, who may then serve as long‐term carriers of the virus.
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Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants.
Nassim Kamar,Nassim Kamar,Cyril Garrouste,Elizabeth B. Haagsma,Valérie Garrigue,Sven Pischke,Cecile Chauvet,Jérôme Dumortier,Amelie Cannesson,Elisabeth Cassuto-Viguier,Eric Thervet,Filomena Conti,Pascal Lebray,Harry R. Dalton,Robert N. Santella,Nada Kanaan,Marie Essig,Christiane Mousson,Sylvie Radenne,Anne Marie Roque-Afonso,Jacques Izopet,Jacques Izopet,Lionel Rostaing,Lionel Rostaing +23 more