Journal ArticleDOI
Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
Fengcai Zhu,Jun Zhang,Xuefeng Zhang,Cheng Zhou,Zhong-Ze Wang,Shoujie Huang,Hua Wang,Chang-Lin Yang,Han-Min Jiang,Jia-Ping Cai,Yi-Jun Wang,Xing Ai,Yuemei Hu,Quan Tang,Xin Yao,Qiang Yan,Yangling Xian,Ting Wu,Yimin Li,Ji Miao,Mun-Hon Ng,James Wai-Kuo Shih,Ningshao Xia +22 more
TLDR
HEV 239 is well tolerated and effective in the prevention of hepatitis E in the general population in China, including both men and women age 16-65 years and no vaccination-related serious adverse event was noted.About:
This article is published in The Lancet.The article was published on 2010-09-11. It has received 620 citations till now. The article focuses on the topics: Hepatitis B vaccine & Vaccine efficacy.read more
Citations
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The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
Jeffrey D. Stanaway,Abraham D. Flaxman,Mohsen Naghavi,Christina Fitzmaurice,Christina Fitzmaurice,Theo Vos,Ibrahim Abubakar,Laith J. Abu-Raddad,Reza Assadi,Neeraj Bhala,Neeraj Bhala,Benjamin C Cowie,Mohammad H. Forouzanfour,Justina Groeger,Khayriyyah Mohd Hanafiah,Khayriyyah Mohd Hanafiah,Kathryn H. Jacobsen,Spencer L. James,Jennifer H MacLachlan,Reza Malekzadeh,Natasha K. Martin,Natasha K. Martin,Ali A. Mokdad,Ali H. Mokdad,Christopher J L Murray,Dietrich Plass,Saleem M Rana,David B. Rein,Jan Hendrik Richardus,Juan Sanabria,Juan Sanabria,Mete Saylan,Saeid Shahraz,Samuel So,Vasiliy Victorovich Vlassov,Elisabete Weiderpass,Steven T. Wiersma,Mustafa Z. Younis,Chuanhua Yu,Maysaa El Sayed Zaki,Graham S Cooke +40 more
TL;DR: The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
Journal ArticleDOI
The global burden of hepatitis E virus genotypes 1 and 2 in 2005
TL;DR: The model was most sensitive to estimates of age‐specific incidence of HEV disease, which causes source‐originated epidemics of acute disease with a case fatality rate thought to vary by age and pregnancy status.
Journal ArticleDOI
Hepatitis E Virus Infection
Nassim Kamar,Nassim Kamar,Harry R. Dalton,Florence Abravanel,Florence Abravanel,Jacques Izopet,Jacques Izopet +6 more
TL;DR: In this comprehensive review, the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries are summarized.
Journal ArticleDOI
EASL Clinical Practice Guidelines on hepatitis E virus infection
Harry R. Dalton,Nassim Kamar,Sally A. Baylis,Darius Moradpour,Heiner Wedemeyer,Francesco Negro +5 more
TL;DR: These Clinical Practice Guidelines will be on HEV genotype 3 (and 4) and show that locally acquired HEV is now the commonest cause of acute viral hepatitis in many European countries.
Journal ArticleDOI
Hepatitis E virus infection.
Nassim Kamar,Jacques Izopet,Nicole Pavio,Rakesh Aggarwal,Alain B. Labrique,Heiner Wedemeyer,Harry R. Dalton +6 more
TL;DR: HEV infections can be diagnosed by measuring anti-HEV antibodies, HEV RNA or viral capsid antigen in blood or stool and management of immunocompromised individuals involves lowering the dose of immunosuppressive drugs and/or treatment with the antiviral agent ribavirin.
References
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Viral hepatitis B
TL;DR: Current available monotherapies-interferon, lamivudine, and adefovir dipivoxil-very rarely eradicate the virus, but greatly reduce its replication, necroinflammatory histological activity, and progression of fibrosis.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis.
TL;DR: In most areas where HEV genotypes 3 and 4 were characterised, sequences from both humans and animals were highly conserved, indicating they originated from the same infectious sources.
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Hepatitis E: an emerging awareness of an old disease.
TL;DR: Although hepatitis E was recognized as a new disease in 1980, the virus was first visualized in 1983 and its genome was cloned and characterized in 1991, the disease is probably ancient but not recognized until modern times.