Book ChapterDOI
Peptidergic sensory neurons in the control of vascular functions: mechanisms and significance in the cutaneous and splanchnic vascular beds.
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This article is published in Reviews of Physiology Biochemistry and Pharmacology.The article was published on 1992-01-01. It has received 232 citations till now. The article focuses on the topics: Splanchnic & Vasoactive intestinal peptide.read more
Citations
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Journal ArticleDOI
Physiological roles and properties of potassium channels in arterial smooth muscle
Mark T. Nelson,J. M. Quayle +1 more
TL;DR: The main conclusions of this review are: 1) regulation of arterial smooth muscle membrane potential through activation or inhibition of K+ channel activity provides an important mechanism to dilate or constrict arteries; 2) KV, KCa, KIR, and KATP channels serve unique functions in the regulation of artery membrane potential
Journal ArticleDOI
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
TL;DR: It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from knowledge concerning this molecule.
Journal ArticleDOI
Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Susan D. Brain,Andrew D. Grant +1 more
TL;DR: The receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin are summarized, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed.
Journal ArticleDOI
Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves
TL;DR: Neuroeffector roles of tachykinins and CGRP released from primary afferent neurons 6.2.1 Pathoph:ysiological implications 6.3.1.
Journal ArticleDOI
Neurogenic Vasodilatation and Plasma Leakage in the Skin
TL;DR: CGRP, SP, and NKA receptor antagonists are powerful pharmacological tools to inhibit neurogenic inflammation at the postjunctional level and have a bearing on chronic inflammatory disease.
References
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Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
Journal ArticleDOI
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
Journal ArticleDOI
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
Journal ArticleDOI
Calcitonin gene-related peptide is a potent vasodilator
TL;DR: It is suggested that local extravascular release of CGRP may be involved in the physiological control of blood flow and that circulating C GRP may contribute to hyperaemia in certain pathological conditions.
Journal ArticleDOI
Immunoproliferative small-intestinal disease. An immunohistochemical study.
TL;DR: Findings confirm the homology between IPSID and low-grade B-cell "Western" lymphomas arising in mucosa-associated lymphoid tissue and suggest that the follicular pattern sometimes seen in these lymphomas is caused by selective colonization of reactive follicles by CCL tumor cells.