Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels.
Reads0
Chats0
TLDR
Data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.Abstract:
The nonsteroidal estrogenic compound bisphenol A (BPA) is a monomer used in the manufacture of polycarbonate plastics and resins. BPA may be ingested by humans as it reportedly leaches from the lining of tin cans into foods, from dental sealants into saliva, and from polycarbonate bottles into their contents. Because BPA is weakly estrogenic--approximately 10,000-fold less potent than 17beta-estradiol--current environmental exposure levels have been considered orders of magnitude below the dose required for adverse effects on health. Herein we demonstrate measurable effects on the offspring of Sprague-Dawley female rats that were exposed, via their drinking water, to approximately 0.1 mg BPA/kg body weight (bw)/day (low dose) or 1.2 mg BPA/kg bw/day (high dose) from day 6 of pregnancy through the period of lactation. Offspring exposed to BPA exhibited an increase in body weight that was apparent soon after birth and continued into adulthood. In addition, female offspring exposed perinatally to the high dose of BPA exhibited altered patterns of estrous cyclicity and decreased levels of plasma luteinizing hormone (LH) in adulthood. Administration of neither the doses of BPA that caused effects during perinatal exposure nor a 10-fold higher dose was able to evoke a uterotropic response in ovariectomized postpubertal females. These data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.read more
Citations
More filters
Journal ArticleDOI
Bisphenol A and human health: a review of the literature.
TL;DR: The growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental B PA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Journal ArticleDOI
State of the Science of Endocrine Disrupting Chemicals - 2012
TL;DR: The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of UNEP or WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
Journal ArticleDOI
An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.
TL;DR: It is proposed that a new risk assessment for BPA is needed based on the extensive new literature reporting adverse effects in animals at doses below the current reference dose, and the high rate of leaching of BPA from food and beverage containers, leading to widespread human exposure.
Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
TL;DR: Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.
References
More filters
Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Journal ArticleDOI
Sexual differentiation of the central nervous system
TL;DR: In many higher vertebrates, an integral part of this process is the induction of permanent and essentially irreversible sex differences in central nervous function, in response to gonadal hormones secreted early in development.
Book
Chemically-induced alterations in sexual and functional development : the wildlife/human connection
Theo Colborn,Coralie Clement +1 more
TL;DR: The role of mesenchyme in the development of the urogenital tract was discussed by Howard A. Bern and M.M. van Saal as discussed by the authors, who found evidence of contaminant-induced alterations in sexual development in free-living wildlife.
Journal ArticleDOI
Estrogenicity of resin-based composites and sealants used in dentistry.
Nicolás Olea,Rosa Pulgar,Pilar Perez,Fátima Olea-Serrano,Ana Rivas,Arantzazu Novillo-Fertrell,V. Pedraza,Ana M. Soto,Carlos Sonnenschein +8 more
TL;DR: The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.