Journal ArticleDOI
Periodontal systemic associations: review of the evidence.
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TLDR
There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases and there was substantial heterogeneity in the definitions used to identifyperiodontitis.Abstract:
Aim: To critically appraise recent research into associations between periodontal disease and systemic diseases and conditions specifically respiratory disease, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer. Methods: A MEDLINE literature search of papers published between 2002 and April 2012 was conducted. Studies that included periodontitis as an exposure were identified. Cross-sectional epidemiological investigations on large samples, prospective studies and systematic reviews formed the basis of the narrative review. A threshold set for the identification of periodontitis was used to identify those studies that contributed to the conclusions of the review. Results: Many of the investigations were cross-sectional secondary analyses of existing data sets in particular the NHANES studies. There were a small number of systematic reviews and prospective studies. There was substantial variability in the definitions of exposure to periodontitis. A small number of studies met the threshold set for periodontitis and supported associations; however, in some of the chronic diseases there were no such studies. There was strong evidence from randomized controlled trials that interventions, which improve oral hygiene have positive effects on the prevention of nosocomial pneumonias. Conclusions: There was substantial heterogeneity in the definitions used to identify periodontitis and very few studies met a stringent threshold for periodontitis. Published evidence supports modest associations between periodontitis and some, although not all, of the diseases and conditions reviewed. There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases.read more
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Journal ArticleDOI
Periodontitis and cardiovascular diseases: Consensus report
Mariano Sanz,Alvaro Marco del Castillo,Søren Jepsen,José Ramón González-Juanatey,Francesco D'Aiuto,Philippe Bouchard,Iain L. C. Chapple,Thomas Dietrich,Israel Gotsman,Filippo Graziani,David Herrera,Bruno G. Loos,Phoebus N. Madianos,Jean-Baptiste Michel,Pablo Perel,Pablo Perel,Burkert Pieske,Lior Shapira,Michael Shechter,Maurizio S. Tonetti,Charalambos Vlachopoulos,Gernot Wimmer +21 more
TL;DR: The present review reports the proceedings of the workshop jointly organised by the EFP and the World Heart Federation, which has updated the existing epidemiological evidence for significant associations between periodontitis and CVD, the mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes.
Journal ArticleDOI
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases
TL;DR: Recent evidence for the interrelationship between chronic periodontitis and other prevalent chronic diseases such as cardiovascular diseases, diabetes, cancer and chronic respiratory diseases is summarized and inflammatory cytokines such as TNF-alpha, IL-1, and IL-6 are focused on.
Journal ArticleDOI
Effect of Periodontitis on Overt Nephropathy and End-Stage Renal Disease in Type 2 Diabetes Response to Varon
Wendy A. Shultis,E. Jennifer Weil,Helen C. Looker,Jeffrey M. Curtis,Marc Shlossman,Robert J. Genco,William C. Knowler,Robert G. Nelson +7 more
TL;DR: periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes and whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined.
Journal ArticleDOI
Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way
Fábio Sá Carneiro Sczepanik,Márcio Lima Grossi,Márcio Zaffalon Casati,Michael B. Goldberg,Michael B. Goldberg,Michael Glogauer,Michael Glogauer,Michael Glogauer,Noah Fine,Noah Fine,Howard C. Tenenbaum,Howard C. Tenenbaum +11 more
TL;DR: It is suggested that upregulation of reactive oxygen species might play one of the most important roles in the establishment and progression of periodontitis (as well as in other diseases of inflammation) through the development of oxidative stress.
Journal ArticleDOI
Microbiota, cirrhosis, and the emerging oral-gut-liver axis
TL;DR: A review of cirrhosis treatment modalities will highlight the emerging role of the oral-gut-liver axis and introduce perspectives for future research.
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