Persistent Sodium Current and Its Role in Epilepsy
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TLDR
A burgeoning literature is documenting mutations in sodium channels that underlie human disease, including epilepsy, that lead to altered neuronal excitability by increasing INaP, which is activated in the subthreshold voltage range and is capable of amplifying a neuron's response to synaptic input and enhancing its repetitive firing capability.Abstract:
Sodium currents are essential for the initiation and propagation of neuronal firing. Alterations of sodium currents can lead to abnormal neuronal activity, such as occurs in epilepsy. The transient voltage-gated sodium current mediates the upstroke of the action potential. A small fraction of sodium current, termed the persistent sodium current (INaP), fails to inactivate significantly, even with prolonged depolarization. INaP is activated in the subthreshold voltage range and is capable of amplifying a neuron's response to synaptic input and enhancing its repetitive firing capability. A burgeoning literature is documenting mutations in sodium channels that underlie human disease, including epilepsy. Some of these mutations lead to altered neuronal excitability by increasing INaP. This review focuses on the pathophysiological effects of INaP in epilepsy.read more
Citations
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Mechanisms of action of currently used antiseizure drugs.
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Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies.
Julia Oyrer,Snezana Maljevic,Ingrid E. Scheffer,Samuel F. Berkovic,Steven Petrou,Christopher A. Reid +5 more
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A Potassium Channel Mutation in Neonatal Human Epilepsy
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