Journal ArticleDOI
Pharmaceutical salts of ciprofloxacin with dicarboxylic acids
Artem O. Surov,Alex N. Manin,Alexander P. Voronin,Ksenia V. Drozd,Anna A. Simagina,Andrei V. Churakov,German L. Perlovich +6 more
Reads0
Chats0
TLDR
New salts of antibiotic drug ciprofloxacin with pharmaceutically acceptable maleic (Mlt), fumaric (Fum) and adipic (Adp) acids were obtained and their crystal structures were determined.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2015-09-18. It has received 58 citations till now. The article focuses on the topics: Solubility & Adipate.read more
Citations
More filters
Journal ArticleDOI
Transparent ciprofloxacin-povidone antibiotic films and nanofiber mats as potential skin and wound care dressings
Marco Contardi,José A. Heredia-Guerrero,Giovanni Perotto,Paola Valentini,Pier Paolo Pompa,Raffaele Spanò,Luca Goldoni,Rosalia Bertorelli,Athanassia Athanassiou,Ilker S. Bayer +9 more
TL;DR: The fact that PVP/Cipro solutions in aqueous acetic acid can be used either to produce transparent soft films or nanofiber mats renders this process highly suitable for the fabrication of new‐generation potential dressings for wound management and care.
Journal ArticleDOI
Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens
Špela Zupančič,Liis Preem,Julijana Kristl,Marta Putrinš,Tanel Tenson,Petra Kocbek,Karin Kogermann +6 more
TL;DR: The results showed that the structural properties of nanofiber mat are crucial in particular drug‐polymer combinations, affecting the drug release and consequently the antibacterial activity.
Journal ArticleDOI
Chiral halogen and chalcogen bonding receptors for discrimination of stereo- and geometric dicarboxylate isomers in aqueous media.
TL;DR: Novel chiral halogen and chalcogen bonding receptors exhibit different selectivities for stereo- and geometric dicarboxylate isomers compared to a hydrogen bonding analogue.
Journal ArticleDOI
Novel drug–drug cocrystals of carbamazepine with para-aminosalicylic acid: screening, crystal structures and comparative study of carbamazepine cocrystal formation thermodynamics
TL;DR: In this article, the cocrystal formation of the anticonvulsant drug carbamazepine (CBZ) with para-aminosalicylic acid (PASA, antituberculous drug) has been studied by varying the molar ratios of CBZ to PASA and using liquid-assisted grinding (LAG), slurrying and solution crystallization methods.
Journal ArticleDOI
Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies.
TL;DR: Experimental multistage cocrystal screening of the antituberculous drug 4‐aminosalicylic acid (PASA) has been conducted and cocrystallization has been shown to lead not only to PASA solubility improving but also to its higher stability against the chemical decomposition.
References
More filters
Journal ArticleDOI
A short history of SHELX
TL;DR: This paper could serve as a general literature citation when one or more of the open-source SH ELX programs (and the Bruker AXS version SHELXTL) are employed in the course of a crystal-structure determination.
Journal ArticleDOI
Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals
TL;DR: In this article, a review of the most promising systematic approaches to resolving this enigma was initially developed by the late M. C. Etter, who applied graph theory to recognize, and then utilize, patterns of hydrogen bonding for the understanding and design of molecular crystals.
Journal ArticleDOI
Encoding and decoding hydrogen-bond patterns of organic compounds
Journal ArticleDOI
Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications.
TL;DR: Viable formulation options for poorly water-soluble drugs, such as crystal modification, micronization, amorphization, self-emulsification, cyclodextrin complexation, and pH modification are reviewed on the basis of the biopharmaceutics classification system of drug substances.
Journal ArticleDOI
The Salt−Cocrystal Continuum: The Influence of Crystal Structure on Ionization State
TL;DR: Modifications to the DeltapK(a) rule for selecting salt screen counterions are proposed that focus on the discovery of solid forms with useful physical properties rather than an arbitrary cutoff value for Deltam(a).