Journal ArticleDOI
Pharmacological activities of dehydroepiandrosterone: A review
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TLDR
DHEA is known as an anti-ageing hormone, in osteoporosis and in dementia, and can be used as a supplement as directed by the physician in various condition.About:
This article is published in Steroids.The article was published on 2020-01-01. It has received 33 citations till now. The article focuses on the topics: Dehydroepiandrosterone & Steroid hormone.read more
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Journal ArticleDOI
The role of diosgenin in diabetes and diabetic complications.
TL;DR: The effects of diosgenin through multiple targets and multiple pathways in diabetes and its complications which including diabetic nephropathy, diabetic liver disease, diabetic neuropathy, diabetic vascular disease, diabetes cardiomyopathy, diabetic reproductive dysfunction, and diabetic eye disease are reviewed.
Journal ArticleDOI
TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism
Jie Cheng,Yan Huang,Xiao-Hui Zhang,Yue Yu,Shumin Wu,Jing Jiao,Linh M. Tran,Wanru Zhang,Ran Liu,Liuzhen Zhang,Mei Wang,Mengyao Wang,Wenyu Yan,Yilin Wu,Fangtao Chi,Peng Jiang,Xin-Xiang Zhang,Hong Wu,Hong Wu +18 more
TL;DR: A reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis is shown which suggests that blockade of this reciprocal crosStalk mechanism may have a therapeutic benefit for cancers with PTEN loss or PI3k/ AKT activation.
Journal ArticleDOI
The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review.
Fengcui Sun,Xiufen Yang,Chaoqun Ma,Shizhao Zhang,Lu Yu,Haifei Lu,Guoliang Yin,Pengpeng Liang,Yanan Feng,Fengxia Zhang +9 more
TL;DR: In this paper, the authors evaluated the latest evidence related to diosgenin and hyperlipidemia from clinical and animal studies, including its role in inhibition of intestinal absorption of lipids, regulation of cholesterol transport, promotion of cholesterol conversion into bile acid and its excretion, inhibition of endogenous lipid biosynthesis, antioxidation and lipoprotein lipase activity and regulation of transcription factors related to lipid metabolism.
Journal ArticleDOI
Antiaging agents: safe interventions to slow aging and healthy life span extension
TL;DR: A review on the properties of slow aging and healthy life span extension of natural products from various biological resources, endogenous substances, drugs, and synthetic compounds, as well as the mechanisms of targets for antiaging evaluation are discussed in this paper .
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Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals
TL;DR: The potential use of DHEA in conjunction with cortisol to improve the definition of the stress phenotype in farmed animals is discussed and the extra-adrenal contribution to circulating D HEA is explored.
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Journal ArticleDOI
Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
Fernand Labrie,Van Luu-The,Claude Labrie,Alain Bélanger,Jacques Simard,Sheng-Xiang Lin,Georges Pelletier +6 more
TL;DR: DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
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The Effect of Six Months Treatment With a 100 Mg Daily Dose of Dehydroepiandrosterone (DHEA) on Circulating Sex Steroids, Body Composition and Muscle Strength in Age-Advanced Men and Women
TL;DR: The effect of a larger dose (100 mg) of DHEA for a longer duration (6 months) on circulating sex steroids, body composition (DEXA) and muscle strength (MedX) was assessed.
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Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits.
TL;DR: Natural androgens inhibit aortic atherosclerosis in castrated male rabbits only partly through a lipid-mediated effect, and ANCOVA indicated that the androgen effect on aorto-atherosclerosis was only in part explained by the changes in lipoproteins.
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Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study.
Charles Couillard,Jacques Gagnon,Jean Bergeron,Arthur S. Leon,Dabeeru C. Rao,James S. Skinner,Jack H. Wilmore,Jean-Pierre Després,Claude Bouchard +8 more
TL;DR: It is suggested that age-related differences in plasma steroid hormone levels, especially androgens, are partly mediated by concomitant variation in adiposity in men.
Journal ArticleDOI
Endogenous sex hormones and cardiovascular disease in men.
TL;DR: The studies reviewed in this article suggest that circulating endogenous sex hormones and estrogens have a neutral or beneficial effect on cardiovascular disease in men.