Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4-Amplified Well-Differentiated or Dedifferentiated Liposarcoma
Mark A. Dickson,William D. Tap,Mary Louise Keohan,Sandra P. D'Angelo,Mrinal M. Gounder,Cristina R. Antonescu,Jonathan Landa,Li-Xuan Qin,Dustin D. Rathbone,Mercedes M. Condy,Yelena Ustoyev,Aimee M. Crago,Samuel Singer,Gary K. Schwartz +13 more
TLDR
Treatment with theCDK4 inhibitor PD0332991 was associated with a favorable progression-free rate in patients with CDK4-amplified and RB-expressing WDLS/DDLS who had progressive disease despite systemic therapy.Abstract:
Purpose CDK4 is amplified in 90% of well-differentiated (WDLS) and dedifferentiated liposarcomas (DDLS). The selective cyclin-dependent kinase 4 (CDK4)/CDK6 inhibitor PD0332991 inhibits growth and induces senescence in cell lines and xenografts. In a phase I trial of PD0332991, several patients with WDLS or DDLS experienced prolonged stable disease. We performed an open-label phase II study to determine the safety and efficacy of PD0332991 in patients with advanced WDLS/DDLS.read more
Citations
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Significant and durable clinical benefit from trastuzumab in 2 patients with HER2-amplified salivary gland cancer and a review of the literature.
Lauren M. Thorpe,Alexa B. Schrock,Rachel L. Erlich,Vincent A. Miller,James A. Knost,Nguyet Le‐Lindqwister,Srinivas Jujjavarapu,Siraj M. Ali,Jane Liu +8 more
TL;DR: Salivary ductal carcinoma and carcinoma ex pleomorphic adenoma (CEPA) are aggressive salivary gland cancers with poor prognosis.
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An update for Richter syndrome – new directions and developments
TL;DR: Novel agents in development are discussed with a focus on the second‐generation Bruton tyrosine kinase inhibitor acalabrutinib, checkpoint inhibition and the potential role of precision medicine in future trials of RS.
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Combining Targeted Agents With Modern Radiotherapy in Soft Tissue Sarcomas
Philip Wong,Peter J. Houghton,David G. Kirsch,Steven E. Finkelstein,Arta M. Monjazeb,Meng Xu-Welliver,Adam P. Dicker,Mansoor M. Ahmed,Bhadrasain Vikram,Beverly A. Teicher,C. Norman Coleman,Mitchell Machtay,Walter J. Curran,Dian Wang +13 more
TL;DR: A strategic vision for clinical translation of preclinical findings is outlined and appropriate targeted agents to combine with radiotherapy in the treatment of STS from different sites and/or different histology subtypes are identified.
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Managing Liposarcomas: Cutting Through the Fat
TL;DR: It is critical that liposarcomas are not approached by oncologists as one disease entity but rather subclassified into distinct subtypes using histologic and molecular tools before formalizing a treatment plan.
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Cyclin-dependent kinase 4/6 inhibitors in breast cancer therapy.
TL;DR: Preclinical and clinical data suggest that CDK4/6 inhibitors might be particularly useful in patients with hormone-receptor-positive or HER2-positive tumors, whereas the role of such inhibitors in triple-negative breast cancer is still controversial.
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