Journal ArticleDOI
Phase separation drives tumor pathogenesis and evolution: all roads lead to Rome
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TLDR
The drivers and functions of phase separation are summarized, the roles ofphase separation in tumor pathogenesis and evolution are elaborate, and substantial research and therapeutic prospects for phase separation in cancer are proposed.About:
This article is published in Oncogene.The article was published on 2022-02-08. It has received 3 citations till now. The article focuses on the topics: Medicine & Intracellular.read more
Citations
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From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies
TL;DR: In this paper , the authors highlight some general principles in the organization and evolution of cancerous tumors, which objectively lead to their enormous variability and, consequently, the irreproducibility of the results of their investigation.
Journal ArticleDOI
A model for identification of potential phase-separated proteins based on protein sequence, structure and cellular distribution.
TL;DR: In this article , a workflow for screening phase-separated proteins and identifying a cell cycle-related phase separation protein, serine/arginine-rich splicing factor 2 (SRSF2), was developed.
Journal ArticleDOI
Protein Phase Separation: New Insights into Carcinogenesis
Yan Luo,Shasha Xiang,Jianbo Feng +2 more
TL;DR: The potential of phase separation as a new field of cancer research in addressing the unmet clinical needs of patients with cancer is discussed in this article . But, the relationship between phase separation and cancer has not been fully elucidated.
References
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Journal ArticleDOI
The cancer genome
Michael R. Stratton,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell,P. Andrew Futreal +4 more
TL;DR: This work has shown that the complete DNA sequence of large numbers of cancer genomes will be possible to obtain and will provide a detailed and comprehensive perspective on how individual cancers have developed.
Journal ArticleDOI
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: In this article, the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, called super-enhancers, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
Journal ArticleDOI
Super-Enhancers in the Control of Cell Identity and Disease
Denes Hnisz,Brian J. Abraham,Tong Ihn Lee,Ashley Lau,Violaine Saint-André,Alla A. Sigova,Heather A. Hoke,Richard A. Young +7 more
TL;DR: The super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity and play key roles in human cell identity in health and in disease as mentioned in this paper.
Journal ArticleDOI
Cancer epigenetics: from mechanism to therapy.
Mark A. Dawson,Tony Kouzarides +1 more
TL;DR: The basic principles behind DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting are presented and the evidence suggesting that their misregulation can culminate in cancer is highlighted.
Journal ArticleDOI
Liquid phase condensation in cell physiology and disease.
TL;DR: The findings together suggest that several membrane-less organelles have been shown to exhibit a concentration threshold for assembly, a hallmark of phase separation, and represent liquid-phase condensates, which form via a biologically regulated (liquid-liquid) phase separation process.
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