Journal ArticleDOI
Phenolic extracts from various Algerian plants as strong inhibitors of porcine liver carboxylesterase.
TLDR
Results indicate that the Phenolic extracts from these plants lead to the inactivation of the CE pI = 5.1 with Ki values in micromolar range (1.4–38 μM), which encourages further biological investigation and identification the inhibitors responsible for this activity.Abstract:
Carboxylesterases (CE), expressed at high levels in human liver and intestine, are thought to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds from several plants from the Algerian Atlas used traditionally in Arab folk medicine on the enzymatic activity of porcine liver carboxylesterase. The plants have shown a potent inhibition of carboxylesterase (CE) enzymatic activity in a concentration-dependent manner. Results indicate that the Phenolic extracts from these plants lead to the inactivation of the CE pI = 5.1 with Ki values in micromolar range (1.4–38 μM). These results encourage further biological investigation and identification the inhibitors responsible for this activity.read more
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Purple Corn (Zea mays L.) Phenolic Compounds Profile and Its Assessment as an Agent Against Oxidative Stress in Isolated Mouse Organs
TL;DR: In this article, a study was designed to determine the contents of total polyphenols, anthocyanins, flavonoids and flavanols of purple corn (Zea mays L) extracts obtained with different methanol:water concentrations, acidified with 1% HCl (1 N).
Journal ArticleDOI
Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl4-induced hepatotoxicity.
TL;DR: Results demonstrate that chicory extract is rich in natural antioxidants and able to attenuate CCl4-induced hepatocellular injury, likely by scavenging reactive free radicals, boosting the endogenous antioxidant defense system, and overexpressing genes encoding antioxidant enzymes.
Journal ArticleDOI
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
M. Jason Hatfield,Lyudmila Tsurkan,Janice L. Hyatt,Carol C. Edwards,Andrew Lemoff,Cynthia Jeffries,Bing Yan,Philip M. Potter +7 more
TL;DR: It is concluded that remedies containing tanshinones should be avoided when individuals are taking esterified agents and that patients should be warned of the potential drug-drug interaction that may occur with this material.
Journal ArticleDOI
Evaluation of In Vitro Antioxidant and Antidiabetic Activities of Aristolochia longa Extracts
Nasreddine El Omari,Karima Sayah,Saad Fettach,Omar El Blidi,Abdelhakim Bouyahya,My El Abbes Faouzi,Rabie Kamal,Malika Barkiyou +7 more
TL;DR: The evaluation of in vitro antioxidant activity and inhibitory potential of organic extracts from Aristolochia longa roots against key enzymes linked to hyperglycemia showed that this plant could be a significant source of medically important natural compounds.
Journal ArticleDOI
Antioxidant activity of phenolic and flavonoid fractions of Cleome gynandra and Maerua angolensis of Burkina Faso
TL;DR: In this article, the anti-FRAP, anti-ABTS and anti-DPPH were evaluated with a sample concentration at 100 µg/mL and three methods, i.e., FRAP, ABTS and DPPH were used to estimate the total antioxidant capacity of the plants fractions.
References
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Journal ArticleDOI
Use of a Free Radical Method to Evaluate Antioxidant Activity
TL;DR: The antiradical properties of various antioxidants were determined using the free radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH*) in its radical form as discussed by the authors.
Journal Article
Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
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Antioxidant Determinations by the Use of a Stable Free Radical
TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.
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Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
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Studies and perspectives of protein kinase C
TL;DR: A novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to the understanding of cell-to-cell communication.