Placental protein 13 (PP13/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome
Andrea Balogh,Judit Pozsgay,János Matkó,János Matkó,Zhong Dong,Chong Jai Kim,Tibor Várkonyi,Marei Sammar,János Rigó,Hamutal Meiri,Roberto Romero,Zoltán Papp,Nandor Gabor Than,Nandor Gabor Than +13 more
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TLDR
PP13 is released from the syncytiotrophoblast in preterm preeclampsia and HELLP, mimicked in BeWo cells by ischemic stress, suggesting PP13 is a placental alarmin.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2011-08-01 and is currently open access. It has received 53 citations till now. The article focuses on the topics: Actin cytoskeleton & Syncytiotrophoblast.read more
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Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review.
Ulrich Abildgaard,Ketil Heimdal +1 more
TL;DR: The pathogenetic mechanisms of HELLP syndrome are reviewed with an emphasis on differences between HELLP and early onset PE.
Journal ArticleDOI
The endocrine function of human placenta: an overview.
TL;DR: This review proposes to revise and update the main pregnancy-related hormones, addressing their major characteristics, molecular targets, function throughout pregnancy, regulators of their expression and their potential clinical interest.
Journal ArticleDOI
Placental Protein 13 (PP13) - A Placental Immunoregulatory Galectin Protecting Pregnancy.
Nandor Gabor Than,Andrea Balogh,Roberto Romero,Éva Kárpáti,Offer Erez,András Szilágyi,Ilona Kovalszky,Marei Sammar,Sveinbjörn Gizurarson,János Matkó,Péter Závodszky,Zoltán Papp,Hamutal Meiri +12 more
TL;DR: The meta-analysis suggests that this phenomenon may enable the potential use of PP13 in directing patient management near to or at the time of delivery, and suggests its therapeutic potential in preeclampsia.
Journal ArticleDOI
Galectins: guardians of eutherian pregnancy at the maternal–fetal interface
Nandor Gabor Than,Roberto Romero,Chong Jai Kim,Chong Jai Kim,Michael R. McGowen,Zoltán Papp,Derek E. Wildman,Derek E. Wildman +7 more
TL;DR: Based on published evidence, galectins expressed at the maternal- Fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectin may facilitate the prediction, prevention, diagnosis, and treatment of pregnancy complications.
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Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia.
Harvey J. Kliman,Marei Sammar,Y. I. Grimpel,S. K. Lynch,Kristin M. Milano,Elah Pick,J. Bejar,A. Arad,J. J. Lee,Hamutal Meiri,Ron Gonen +10 more
TL;DR: It is hypothesized that PP13 is secreted into the intervillus space, drains through the decidua basalis veins, and forms perivenous PP13 aggregates which attract and activate maternal immune cells.
References
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Journal ArticleDOI
Tolerance, danger, and the extended family.
TL;DR: The possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues is discussed.
Journal ArticleDOI
A guided tour into subcellular colocalization analysis in light microscopy
TL;DR: A novel toolbox for subcellular colocalization analysis under ImageJ is created that integrates current global statistic methods and a novel object‐based approach to assess proteins residing on intracellular structures by fluorescence microscopy.
Journal ArticleDOI
DAMPs, PAMPs and alarmins: all we need to know about danger
TL;DR: The term “alarmin” is proposed to categorize such endogenous molecules that signal tissue and cell damage, and can be considered subgroups of a larger set, the damage‐associated molecular patterns (DAMPs).
Journal ArticleDOI
Latest advances in understanding preeclampsia.
TL;DR: Recent work on the causes of preeclampsia is summarized, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition, and circulating factors derived from the placenta are now better understood.
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