Galectins: guardians of eutherian pregnancy at the maternal–fetal interface
Nandor Gabor Than,Roberto Romero,Chong Jai Kim,Chong Jai Kim,Michael R. McGowen,Zoltán Papp,Derek E. Wildman,Derek E. Wildman +7 more
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TLDR
Based on published evidence, galectins expressed at the maternal- Fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectin may facilitate the prediction, prevention, diagnosis, and treatment of pregnancy complications.Abstract:
Galectins are multifunctional regulators of fundamental cellular processes. They are also involved in innate and adaptive immune responses, and play a functional role in immune-endocrine crosstalk. Some galectins have attracted attention in the reproductive sciences because they are highly expressed at the maternal-fetal interface, their functional significance in eutherian pregnancies has been documented, and their dysregulated expression is observed in the 'great obstetrical syndromes'. The evolution of these galectins has been linked to the emergence of eutherian mammals. Based on published evidence, galectins expressed at the maternal-fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectins may facilitate the prediction, prevention, diagnosis, and treatment of pregnancy complications.read more
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Only humans have human placentas: molecular differences between mice and humans
TL;DR: It is considered that many aspects of human placentation can only be understood on the basis of experiments on human cells and tissues in combination with data collections from human subject studies, and that the mouse model is often overvalued.
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Placenta-derived exosomes: potential biomarkers of preeclampsia.
TL;DR: In this paper, a review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia, using keywords, online databases were searched to identify relevant publications.
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Placental Protein 13 (PP13) - A Placental Immunoregulatory Galectin Protecting Pregnancy.
Nandor Gabor Than,Andrea Balogh,Roberto Romero,Éva Kárpáti,Offer Erez,András Szilágyi,Ilona Kovalszky,Marei Sammar,Sveinbjörn Gizurarson,János Matkó,Péter Závodszky,Zoltán Papp,Hamutal Meiri +12 more
TL;DR: The meta-analysis suggests that this phenomenon may enable the potential use of PP13 in directing patient management near to or at the time of delivery, and suggests its therapeutic potential in preeclampsia.
Journal ArticleDOI
Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia
TL;DR: It is shown that low serum levels of PP13 in the first trimester of pregnancy can predict the development of pre-eclampsia later in pregnancy, a new direction to transfer from individualized risk to personalized prevention.
Journal ArticleDOI
Evolutionary origins of the placental expression of chromosome 19 cluster galectins and their complex dysregulation in preeclampsia.
Nandor Gabor Than,Roberto Romero,Yi Xu,Offer Erez,Zhonghui Xu,Gaurav Bhatti,Ron Leavitt,Tzu Hung Chung,Haidy El-Azzamy,Christopher LaJeunesse,Bing Wang,Andrea Balogh,Andrea Balogh,Gabor Szalai,Susan Land,Zhong Dong,Sonia S. Hassan,Sonia S. Hassan,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Manuel Krispin,Chong Jai Kim,Chong Jai Kim,Adi L. Tarca,Adi L. Tarca,Zoltán Papp,Hans Bohn +26 more
TL;DR: The evolutionary origins of the placental expression of Chr19 cluster galectin genes are revealed and the complex dysregulation of these genes in preeclampsia may alter immune tolerance mechanisms at the maternal-fetal interface.
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