Journal ArticleDOI
Plant extracts as modulators of genotoxic effects
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TLDR
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants, and plant extracts able to modify the process of mutagenesis, which involves alteration in the genetic material are extended.Abstract:
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants. The property of preventing carcinogenesis has been reported in many plant extracts. The observation of a close association between carcinogenesis and mutagenesis has extended the survey to include plant extracts and plant products able to modify the process of mutagenesis, which involves alteration in the genetic material. Natural plant products may, apart from inducing mutations, modify the action of other known mutagens on the living organisms by 1) activating the existing mutagens within the cell, 2) inhibiting the production of mutagens in the cell, 3) synergising the activity of existing mutagens, or 4) activating the promutagens within the cell into mutagens. This review deals with data obtained in the course of research on the modulatory effects of plant extracts on mutagenesis and clastogenesis, two genotoxic phenomena associated with carcinogenesis.read more
Citations
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Journal ArticleDOI
Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts.
TL;DR: High content of ellagitannins is revealed which might be responsible for promising antioxidant and antimutagenic activities of P. granatum peel extract which is to be explored to understand the exact mechanism of action as well as their therapeutic efficacy.
Journal ArticleDOI
Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice.
TL;DR: The data indicate that the possible mechanism of inhibition by plant extract is mediated by its modulatory effect on hepatic activation and disposition processes.
Journal ArticleDOI
Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury.
Sanja Matić,Snežana Stanić,Desanka Bogojević,Melita Vidaković,Nevena Grdović,Svetlana Dinić,Slavica Solujic,Milan Mladenović,Nevena Stanković,Mirjana Mihailović +9 more
TL;DR: The results suggest that pro-surviving Akt activity and STAT3 protein expression play important roles in decreasing DNA damage and in mediating hepatic protection by the methanol extract of C. coggygria against pyrogallol-induced toxicity.
Journal ArticleDOI
Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems
TL;DR: The results showed that the highest concentration of aqueous extracts reduced the mitotic index, the seed germination and the root development of lettuce, and the extracts have also induced chromosome aberrations and cellular death in the roots cells of L. sativa.
Book ChapterDOI
Potential Genotoxic and Cytotoxic Effects of Plant Extracts
TL;DR: The medicinal use of plants is probably as old as human kind itself and many of the plants species used for this purpose have been found to contain therapeutic substances which can be extracted and used in preparation of drugs.
References
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Journal ArticleDOI
A desmutagenic factor isolated from burdock (Arctium lappa Linne).
TL;DR: A desmutagenic factor was isolated from burdock and showed characteristics of a polyanionic substance and an irreversible diminution of the mutagen was confirmed by treatment of 2-NO2-1,4-DAB or Trp-P-2 with the burdock factor.
Journal ArticleDOI
Antimutagenicity of some citrus fruits in Salmonella typhimurium.
Saroj Bala,I.S. Grover +1 more
TL;DR: The antimutagenic effect of 10 citrus fruit juices was observed against the mutagenicity of N-nitro-o-phenylenediamine (NPD) in TA97a and sodium azide in TA100 tester strains of Salmonella typhimurium using the Ames test, tempting us to believe that in addition to ascorbic acid and citric acid, the presence of other factor(s) possessing antimUTagenic properties cannot be ruled out.
Journal ArticleDOI
Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo.
TL;DR: The clastogenicity of all three mutagens were reduced significantly in the animals which had been given garlic extract as dietary supplement and may be attributed to the interaction with the different components of the extract.
Journal ArticleDOI
Mutagenic activation of xenobiotics by plant enzymes
TL;DR: In analogy to results obtained in mammalian systems, covalent binding of reactive intermediates to DNA as well as fragmentation of DNA, are proposed as major mechanisms of action of mutagenic plant metabolites.
Journal ArticleDOI
Augmentation of urinary amylase output by excessive diuresis in rats and abolition of this phenomenon by pancreatectomy
TL;DR: Urinary amylase output was significantly augmented by excessive diuresis and that the increased urinary amyl enzyme output originated from the pancreas.