Journal ArticleDOI
Plant extracts as modulators of genotoxic effects
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TLDR
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants, and plant extracts able to modify the process of mutagenesis, which involves alteration in the genetic material are extended.Abstract:
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants. The property of preventing carcinogenesis has been reported in many plant extracts. The observation of a close association between carcinogenesis and mutagenesis has extended the survey to include plant extracts and plant products able to modify the process of mutagenesis, which involves alteration in the genetic material. Natural plant products may, apart from inducing mutations, modify the action of other known mutagens on the living organisms by 1) activating the existing mutagens within the cell, 2) inhibiting the production of mutagens in the cell, 3) synergising the activity of existing mutagens, or 4) activating the promutagens within the cell into mutagens. This review deals with data obtained in the course of research on the modulatory effects of plant extracts on mutagenesis and clastogenesis, two genotoxic phenomena associated with carcinogenesis.read more
Citations
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Journal ArticleDOI
Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts.
TL;DR: High content of ellagitannins is revealed which might be responsible for promising antioxidant and antimutagenic activities of P. granatum peel extract which is to be explored to understand the exact mechanism of action as well as their therapeutic efficacy.
Journal ArticleDOI
Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice.
TL;DR: The data indicate that the possible mechanism of inhibition by plant extract is mediated by its modulatory effect on hepatic activation and disposition processes.
Journal ArticleDOI
Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury.
Sanja Matić,Snežana Stanić,Desanka Bogojević,Melita Vidaković,Nevena Grdović,Svetlana Dinić,Slavica Solujic,Milan Mladenović,Nevena Stanković,Mirjana Mihailović +9 more
TL;DR: The results suggest that pro-surviving Akt activity and STAT3 protein expression play important roles in decreasing DNA damage and in mediating hepatic protection by the methanol extract of C. coggygria against pyrogallol-induced toxicity.
Journal ArticleDOI
Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems
TL;DR: The results showed that the highest concentration of aqueous extracts reduced the mitotic index, the seed germination and the root development of lettuce, and the extracts have also induced chromosome aberrations and cellular death in the roots cells of L. sativa.
Book ChapterDOI
Potential Genotoxic and Cytotoxic Effects of Plant Extracts
TL;DR: The medicinal use of plants is probably as old as human kind itself and many of the plants species used for this purpose have been found to contain therapeutic substances which can be extracted and used in preparation of drugs.
References
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Journal ArticleDOI
Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay.
TL;DR: It was observed that ginger extract, gingerol and shogaol were mutagenic on metabolic activation in strains TA 100 and TA 1535, but zingerone was non-mutagenic in all the four strains with or without S9 mix.
Journal ArticleDOI
Mechanism of antimutagenicity of wheat sprout extracts.
TL;DR: The strong inhibition of BP mutagenicity and BP metabolism with non-chlorophyllic wheat Sprout extract suggests that chlorophyll is not the main compound responsible for the antimutagenic activity of wheat sprout extract.
Journal ArticleDOI
The action of anticlastogens in human lymphocyte cultures and their modification by rat-liver S9 mix. II. Studies with vitamins C and E.
TL;DR: In contrast to their anticlastogenic efficacy neither of the vitamins displayed any significant anti-SCE effect, nor were they active in affecting the inhibition of cell proliferation caused by TR or CP.
Journal ArticleDOI
Suppression of 7,12-dimethylbenz[a]anthracene-induced chromosome aberrations in rat bone marrow cells by vegetable juices
TL;DR: The present results may suggest that some vegetables, such as onion, suppress chemically induced cancer and Glutathione also suppressed DMBA-induced CA.
Journal ArticleDOI
Mutagen and anti-mutagen in ginger, Zingiber officinale
Hakobu Nakamura,Takeshi Yamamoto +1 more
TL;DR: It is suggested that the [6]-gingerol component may be mutagenically activated by the presence of AF2 and NTG.