Journal ArticleDOI
Plant extracts as modulators of genotoxic effects
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TLDR
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants, and plant extracts able to modify the process of mutagenesis, which involves alteration in the genetic material are extended.Abstract:
Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants. The property of preventing carcinogenesis has been reported in many plant extracts. The observation of a close association between carcinogenesis and mutagenesis has extended the survey to include plant extracts and plant products able to modify the process of mutagenesis, which involves alteration in the genetic material. Natural plant products may, apart from inducing mutations, modify the action of other known mutagens on the living organisms by 1) activating the existing mutagens within the cell, 2) inhibiting the production of mutagens in the cell, 3) synergising the activity of existing mutagens, or 4) activating the promutagens within the cell into mutagens. This review deals with data obtained in the course of research on the modulatory effects of plant extracts on mutagenesis and clastogenesis, two genotoxic phenomena associated with carcinogenesis.read more
Citations
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Journal ArticleDOI
Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts.
TL;DR: High content of ellagitannins is revealed which might be responsible for promising antioxidant and antimutagenic activities of P. granatum peel extract which is to be explored to understand the exact mechanism of action as well as their therapeutic efficacy.
Journal ArticleDOI
Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice.
TL;DR: The data indicate that the possible mechanism of inhibition by plant extract is mediated by its modulatory effect on hepatic activation and disposition processes.
Journal ArticleDOI
Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury.
Sanja Matić,Snežana Stanić,Desanka Bogojević,Melita Vidaković,Nevena Grdović,Svetlana Dinić,Slavica Solujic,Milan Mladenović,Nevena Stanković,Mirjana Mihailović +9 more
TL;DR: The results suggest that pro-surviving Akt activity and STAT3 protein expression play important roles in decreasing DNA damage and in mediating hepatic protection by the methanol extract of C. coggygria against pyrogallol-induced toxicity.
Journal ArticleDOI
Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems
TL;DR: The results showed that the highest concentration of aqueous extracts reduced the mitotic index, the seed germination and the root development of lettuce, and the extracts have also induced chromosome aberrations and cellular death in the roots cells of L. sativa.
Book ChapterDOI
Potential Genotoxic and Cytotoxic Effects of Plant Extracts
TL;DR: The medicinal use of plants is probably as old as human kind itself and many of the plants species used for this purpose have been found to contain therapeutic substances which can be extracted and used in preparation of drugs.
References
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Journal ArticleDOI
Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo.
TL;DR: It would be useful to be able to prevent the formation of NOcompounds in food and in vivo, since a number of readily nitrosated drugs are administered orally in largc doses, their possible nitrosation in vivo is particularly disturbing.
Journal ArticleDOI
In vitro antimutagenicity of curcumin against environmental mutagens
TL;DR: Observations indicate that curcumin may alter the metabolic activation and detoxification of mutagens.
Journal ArticleDOI
Crude tea extracts decrease the mutagenic activity of N-methyl-N'-nitro-N-nitrosoguanidine in vitro and in intragastric tract of rats.
TL;DR: The effectiveness of tea extracts for the decrease of MNNG-induced mutagenesis in vitro and in vivo suggests that the habitual drinking of tea may reduce the tumor-initiating potency of N-methyl-N'-nitro-N-nitrosoguanidine compounds if they are formed in the stomach.
Journal ArticleDOI
Mutagenicity of chili extract and capsaicin in short-term tests.
M. Nagabhushan,S. V. Bhide +1 more
TL;DR: Vanillin, capsaicin and chili extracts were tested for mutagenicity in Salmonella typhimurium histidine-deficient tester strains and Capsaicin, an active component of chili extract, was the more potent mutagen.
Journal ArticleDOI
Studies on natural desmutagens: Screening for vegetable and fruit factors active in inactivation of mutagenic pyrolysis products from amino acids
TL;DR: In this article, the authors found that cabbage, broccoli, green pepper, egg plant, apple, burdock, shallot, ginger, pineapple and mint leaf possess strong capacities of inactivating the mutagenicity of tryptophane pyrolysis products.