Journal ArticleDOI
Plasma clearance of intravenously injected aspartate aminotransferase isozymes: evidence for preferential uptake by sinusoidal liver cells.
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TLDR
The tissue distribution of the radioactivity following intravenous administration of 125I‐labeled isozymes revealed that the liver is a major organ involved in plasma clearance of these isoz enzymes, supported by the significant retardation in plasma clearing of m‐AAT in hepatectomized as well as CCI4‐intoxicated rats.About:
This article is published in Hepatology.The article was published on 1985-05-01. It has received 169 citations till now. The article focuses on the topics: Isozyme.read more
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A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
Chun-Tao Wai,Joel K. Greenson,Robert J. Fontana,John D. Kalbfleisch,Jorge A. Marrero,Hari S. Conjeevaram,Anna S.F. Lok +6 more
TL;DR: It is shown that a simple index using readily available laboratory results can identify CHC patients with significant fibrosis and cirrhosis with a high degree of accuracy and may decrease the need for staging liver biopsy specimens among patients with CHC.
Journal ArticleDOI
Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
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Liver enzyme alteration: a guide for clinicians
TL;DR: In this review, a schematic approach is used that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, and abnormal enzymatic activity within the 2 subgroups are reviewed.
Journal ArticleDOI
Evaluation of liver fibrosis: a concise review.
Nezam H. Afdhal,David Nunes +1 more
TL;DR: The current status of liver biopsy as a gold standard for the diagnosis of liver fibrosis is reviewed and the radiological and serum tests that have been proposed as potential adjuncts or alternatives to biopsies are discussed.
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AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection.
TL;DR: The AST/ALT ratio is a dependable marker of fibrosis stage and cirrhosis in patients with chronic HCV infection.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more
TL;DR: Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected, and the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.
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Transaminase activity in human blood
TL;DR: To determine if transaminase activity could be demonstrated in human serum and blood cellular elements and, if so, to study any variations in activity of this enzyme in the blood of normal and diseased man.