Journal ArticleDOI
Plasma needle for in vivo medical treatment: recent developments and perspectives
Eva Stoffels,I.E. Kieft,R.E.J. Sladek,L J M van den Bedem,E.P. van der Laan,M Maarten Steinbuch +5 more
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TLDR
The hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues are described.Abstract:
In this paper we describe the hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues. A specially designed source, plasma needle, is a low-power discharge, which operates under the threshold of tissue damage. When applied properly, the needle does not cause fatal cell injury which would result in cell death (necrosis). Instead, it allows precise and localized cell removal by means of the so-called cell detachment. In addition, plasma can be used for bacterial disinfection. Because of mild treatment conditions, plasma disinfection can be performed in vivo, e.g. on wounds and dental cavities. Presently, one strives to obtain a better control of the operating device. Therefore, plasma has been characterized using a variety of diagnostics, and a smart system has been designed for the positioning of the device with respect to the treated surface.read more
Citations
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Journal ArticleDOI
Micronucleus formation induced by dielectric barrier discharge plasma exposure in brain cancer cells
TL;DR: It is found that micronucleus formation rate directly depends on the plasma exposure time, and it is shown that colony formation capacity of cells has been inhibited by the treatment of plasma at all doses.
Journal ArticleDOI
Delayed Effects of Cold Atmospheric Plasma on Vascular Cells
TL;DR: A not yet resolved phenomenon of total (irreversible) cell inactivation without necrosis was observed in endothelial cells, indicating conditions for non-inflammatory plasma treatment (no cell necrosis) can be realized.
Patent
Ablation apparatus having reduced nerve stimulation and related methods
TL;DR: In this paper, a method for reducing nerve stimulation in electrosurgical instruments utilizing electrically isolated pairs of electrodes is described. But the method is limited to electrosurgery instruments.
Journal ArticleDOI
Optical and electrical characterization of an atmospheric pressure microplasma jet with a capillary electrode
TL;DR: In this article, a microplasma jet with a capillary electrode working at atmospheric pressure is developed to create nonthermal plasma, which can be operated at an excitation frequency either in several tens of kilohertz ac range (or pulsed voltage with a repetition rate of KHz or in radio-frequency range).
Journal ArticleDOI
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
Lei Shi,Fumiya Ito,Yue Wang,Yasumasa Okazaki,Hiromasa Tanaka,Masaaki Mizuno,Masaru Hori,Tasuku Hirayama,Hideko Nagasawa,Des R. Richardson,Shinya Toyokuni,Shinya Toyokuni +11 more
TL;DR: Results suggest NTP acts as a stressor, which results in increased endocytosis, lysosome content and autophagy, and NTP rapidly increased autophagosome formation, as judged by increased LC3B‐II expression, which co‐localized with LAMP1, indicating autophagolysosome formation.
References
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Book
Feedback Control of Dynamic Systems
TL;DR: This introductory book provides an in-depth, comprehensive treatment of a collection of classical and state-space approaches to control system design and ties the methods together so that a designer is able to pick the method that best fits the problem at hand.
Journal ArticleDOI
Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms
TL;DR: In this paper, a review of the literature on plasma sterilization is presented, where three basic mechanisms are involved in the plasma inactivation of microorganisms: (a) direct destruction by UV irradiation of the genetic material of micro organisms; (b) erosion of the microorganisms atom by atom, through intrinsic photodesorption by ultraviolet irradiation to form volatile compounds combining atoms intrinsic to the micro organisms.
Journal ArticleDOI
Nonthermal decontamination of biological media by atmospheric-pressure plasmas: review, analysis, and prospects
TL;DR: A review of various works on the germicidal effects of atmospheric pressure, "cold" plasmas, is presented in this article, where nonequilibrium discharge devices discussed in this review, which have been used in biological applications by various investigators, are the corona discharge, diffuse dielectric-barrier discharge, resistive barrier discharge, and the atmospheric-pressure plasma jet.
Journal ArticleDOI
Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials
TL;DR: In this paper, a non-thermal plasma source (plasma needle) generated under atmospheric pressure by means of radiofrequency excitation has been characterized, which can be applied on organic materials, also in watery environment, without causing thermal/electric damage to the surface.
Patent
Electrosurgical method and apparatus for initiating an electrical discharge in an inert gas flow
TL;DR: An electrosurgical method and apparatus for coagulating by fulguration where the electrical discharge is established through a formation of flowing inert gas where the formation may either be a diffuse blanket of the flowing gas or a well defined column thereof is described in this paper.