Journal ArticleDOI
Plasma needle for in vivo medical treatment: recent developments and perspectives
Eva Stoffels,I.E. Kieft,R.E.J. Sladek,L J M van den Bedem,E.P. van der Laan,M Maarten Steinbuch +5 more
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TLDR
The hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues are described.Abstract:
In this paper we describe the hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues. A specially designed source, plasma needle, is a low-power discharge, which operates under the threshold of tissue damage. When applied properly, the needle does not cause fatal cell injury which would result in cell death (necrosis). Instead, it allows precise and localized cell removal by means of the so-called cell detachment. In addition, plasma can be used for bacterial disinfection. Because of mild treatment conditions, plasma disinfection can be performed in vivo, e.g. on wounds and dental cavities. Presently, one strives to obtain a better control of the operating device. Therefore, plasma has been characterized using a variety of diagnostics, and a smart system has been designed for the positioning of the device with respect to the treated surface.read more
Citations
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Journal ArticleDOI
Investigating effects of atmospheric-pressure plasma on the process of wound healing
TL;DR: This paper compares the spontaneous healing of wounds and a stimulated healing using daily APPJ treatment and demonstrated that an increase in the oxidative stress could result in the decreased destruction of lesions by controlling the infection growth.
Journal ArticleDOI
Comparison of the characteristics of atmospheric pressure plasma jets using different working gases and applications to plasma-cancer cell interactions
TL;DR: In this article, the effects of atmospheric pressure plasma jet on the morphology and intracellular reactive oxygen species (ROS) level of human lung adenocarcinoma cell (A549) and human bladder cancer cell (EJ) were explored.
Journal ArticleDOI
Atomic oxygen patterning from a biomedical needle-plasma source
Sean Kelly,Miles M. Turner +1 more
TL;DR: In this paper, the authors present numerical simulations showing that biologically active reactive oxygen and nitrogen species are produced dominantly where effluent from the plasma needle interacts with ambient air, and a novel solution strategy is utilised coupling plasma produced neutral (uncharged) reactive species to the gas dynamics solving for steady state profiles at the treated biological surface.
Patent
Electrosurgical device with internal digestor electrode
TL;DR: In this paper, an electrosurgical wand is described for treating a target tissue using electrosurgery energy, which has an elongate shaft with a handle end and a distal end.
Patent
System and method of an electrosurgical controller with output RF energy control
TL;DR: In this paper, an electrosurgical controller with output RF energy control is described, which can change a first output voltage on the first active terminal relative to the first return terminal by selective control of a number of turns of the primary winding of a transformer used to create output voltage.
References
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Book
Feedback Control of Dynamic Systems
TL;DR: This introductory book provides an in-depth, comprehensive treatment of a collection of classical and state-space approaches to control system design and ties the methods together so that a designer is able to pick the method that best fits the problem at hand.
Journal ArticleDOI
Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms
TL;DR: In this paper, a review of the literature on plasma sterilization is presented, where three basic mechanisms are involved in the plasma inactivation of microorganisms: (a) direct destruction by UV irradiation of the genetic material of micro organisms; (b) erosion of the microorganisms atom by atom, through intrinsic photodesorption by ultraviolet irradiation to form volatile compounds combining atoms intrinsic to the micro organisms.
Journal ArticleDOI
Nonthermal decontamination of biological media by atmospheric-pressure plasmas: review, analysis, and prospects
TL;DR: A review of various works on the germicidal effects of atmospheric pressure, "cold" plasmas, is presented in this article, where nonequilibrium discharge devices discussed in this review, which have been used in biological applications by various investigators, are the corona discharge, diffuse dielectric-barrier discharge, resistive barrier discharge, and the atmospheric-pressure plasma jet.
Journal ArticleDOI
Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials
TL;DR: In this paper, a non-thermal plasma source (plasma needle) generated under atmospheric pressure by means of radiofrequency excitation has been characterized, which can be applied on organic materials, also in watery environment, without causing thermal/electric damage to the surface.
Patent
Electrosurgical method and apparatus for initiating an electrical discharge in an inert gas flow
TL;DR: An electrosurgical method and apparatus for coagulating by fulguration where the electrical discharge is established through a formation of flowing inert gas where the formation may either be a diffuse blanket of the flowing gas or a well defined column thereof is described in this paper.