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Plasma needle for in vivo medical treatment: recent developments and perspectives

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TLDR
The hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues are described.
Abstract
In this paper we describe the hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues. A specially designed source, plasma needle, is a low-power discharge, which operates under the threshold of tissue damage. When applied properly, the needle does not cause fatal cell injury which would result in cell death (necrosis). Instead, it allows precise and localized cell removal by means of the so-called cell detachment. In addition, plasma can be used for bacterial disinfection. Because of mild treatment conditions, plasma disinfection can be performed in vivo, e.g. on wounds and dental cavities. Presently, one strives to obtain a better control of the operating device. Therefore, plasma has been characterized using a variety of diagnostics, and a smart system has been designed for the positioning of the device with respect to the treated surface.

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Citations
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Patent

A skin treatment device for multiphoton ionization-based skin treatment

TL;DR: In this paper, a non-invasive skin treatment device (200) for generating a multiphoton ionization process at a target position (110) in skin tissue was presented.
Journal ArticleDOI

Two-photon absorption laser induced fluorescence measurement of atomic oxygen density in an atmospheric pressure air plasma jet

TL;DR: In this article, the atomic oxygen number density [O] is measured in an air atmospheric pressure plasma jet (APPJ) using two-photon absorption laser induced fluorescence (TALIF), and the results show that the plasma jet atomic oxygen content increases as the RF power coupled into the plasma increases.
Journal Article

Plasma-induced death of HepG2 cancer cells : intracellular effects of reactive species

TL;DR: In this paper, an atmospheric-pressure plasma plume is used to treat HepG2 cells, which can effectively control the intracellular concentrations of reactive oxygen species (ROS), NO and lipid peroxide.
Journal ArticleDOI

Radio Frequency Underwater Discharge Operation and Its Application to Congo Red Degradation

TL;DR: In this paper, a radio frequency (RF) underwater discharge operation was performed for different liquid conductivities driven by different frequencies ranging from 13.56 MHz to 60 MHz, and its application to organic degradation was investigated.
Journal ArticleDOI

Numerical Simulation of Atmospheric Pressure Plasma Jet Using Lattice Boltzmann Method

TL;DR: In this article, a model for calculating the velocity and temperature field of plasma jet by Lattice Boltzmann (LB) method was established, which is simpler and more efficient than the traditional finite difference method.
References
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Book

Feedback Control of Dynamic Systems

TL;DR: This introductory book provides an in-depth, comprehensive treatment of a collection of classical and state-space approaches to control system design and ties the methods together so that a designer is able to pick the method that best fits the problem at hand.
Journal ArticleDOI

Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms

TL;DR: In this paper, a review of the literature on plasma sterilization is presented, where three basic mechanisms are involved in the plasma inactivation of microorganisms: (a) direct destruction by UV irradiation of the genetic material of micro organisms; (b) erosion of the microorganisms atom by atom, through intrinsic photodesorption by ultraviolet irradiation to form volatile compounds combining atoms intrinsic to the micro organisms.
Journal ArticleDOI

Nonthermal decontamination of biological media by atmospheric-pressure plasmas: review, analysis, and prospects

TL;DR: A review of various works on the germicidal effects of atmospheric pressure, "cold" plasmas, is presented in this article, where nonequilibrium discharge devices discussed in this review, which have been used in biological applications by various investigators, are the corona discharge, diffuse dielectric-barrier discharge, resistive barrier discharge, and the atmospheric-pressure plasma jet.
Journal ArticleDOI

Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials

TL;DR: In this paper, a non-thermal plasma source (plasma needle) generated under atmospheric pressure by means of radiofrequency excitation has been characterized, which can be applied on organic materials, also in watery environment, without causing thermal/electric damage to the surface.
Patent

Electrosurgical method and apparatus for initiating an electrical discharge in an inert gas flow

TL;DR: An electrosurgical method and apparatus for coagulating by fulguration where the electrical discharge is established through a formation of flowing inert gas where the formation may either be a diffuse blanket of the flowing gas or a well defined column thereof is described in this paper.
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What medications can u not be on to donate plasma?

In addition, plasma can be used for bacterial disinfection.