Platelet Glycoprotein IIb/IIIa Inhibitors Reduce Mortality in Diabetic Patients With Non–ST-Segment-Elevation Acute Coronary Syndromes
Marco Roffi,Derek P. Chew,Debabrata Mukherjee,Deepak L. Bhatt,Jennifer White,Christopher Heeschen,Christian W. Hamm,David J. Moliterno,Robert M. Califf,Harvey D. White,Neal S. Kleiman,Pierre Theroux,Eric J. Topol +12 more
TLDR
A meta-analysis of the diabetic populations enrolled in the 6 large-scale platelet GP IIb/IIIa inhibitor ACS trials investigated whether diabetic patients with ACS derive particular benefit from platelet glycoprotein (GP) IIb-IIIa receptor inhibition.Abstract:
Background Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this disease may be associated with increased platelet aggregation, we investigated whether diabetic patients with ACS derive particular benefit from platelet glycoprotein (GP) IIb/IIIa receptor inhibition. Methods and Results We performed a meta-analysis of the diabetic populations enrolled in the 6 large-scale platelet GP IIb/IIIa inhibitor ACS trials: PRISM, PRISM-PLUS, PARAGON A, PARAGON B, PURSUIT, and GUSTO IV. Among 6458 diabetic patients, platelet GP IIb/IIIa inhibition was associated with a significant mortality reduction at 30 days, from 6.2% to 4.6% (OR 0.74; 95% CI 0.59 to 0.92; P=0.007). Conversely, 23 072 nondiabetic patients had no survival benefit (3.0% versus 3.0%). The interaction between platelet GP IIb/IIIa inhibition and diabetic status was statistically significant (P=0.036). Among 1279 diabetic patients undergoing percutaneous coronary intervention (PCI) during inde...read more
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2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC)
Marco Roffi,Carlo Patrono,Jean-Philippe Collet,Christian Mueller,Marco Valgimigli,Felicita Andreotti,Jeroen J. Bax,Michael A. Borger,Carlos Brotons,Derek P. Chew,Baris Gencer,Gerd Hasenfuss,Keld Kjeldsen,Patrizio Lancellotti,Ulf Landmesser,Julinda Mehilli,Debabrata Mukherjee,Robert F. Storey,Stephan Windecker +18 more
TL;DR: The current guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation are based on the findings of the ESC Task Force on 12 March 2015.
Journal ArticleDOI
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Christian W. Hamm,Jean-Pierre Bassand,Stefan Agewall,Jeroen J. Bax,Eric Boersma,Héctor Bueno,Pio Caso,Dariusz Dudek,Stephan Gielen,Kurt Huber,Magnus Ohman,Mark C. Petrie,Frank Sonntag,Miguel Sousa Uva,Robert F. Storey,William Wijns,Doron Zahger +16 more
TL;DR: This paper presents a Randomized Assessment of Acute Coronary Syndrome Treatment of Intracoronary Stenting With Antithrombotic Regimen and Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction.
Journal ArticleDOI
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Ezra A. Amsterdam,Nanette K. Wenger,Ralph G. Brindis,Donald E. Casey,Theodore G. Ganiats,David R. Holmes,Allan S. Jaffe,Hani Jneid,Rosemary F. Kelly,Michael C. Kontos,Glenn N. Levine,Philip R. Liebson,Debabrata Mukherjee,Eric D. Peterson,Marc S. Sabatine,Richard W. Smalling,Susan J. Zieman +16 more
TL;DR: In this article, Anderson et al. discuss the FAHA chair election process and discuss the state of the art in the field of cancer research. But they do not discuss the role of women in this process.
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2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
Glenn N. Levine,Eric R. Bates,James C. Blankenship,Steven R. Bailey,John A. Bittl,Bojan Cercek,Charles E. Chambers,Stephen G. Ellis,Robert A. Guyton,Steven M. Hollenberg,Umesh N. Khot,Richard A. Lange,Laura Mauri,Roxana Mehran,Issam Moussa,Debabrata Mukherjee,Brahmajee K. Nallamothu,Henry H. Ting,Alice K. Jacobs,Nancy M. Albert,Mark A. Creager,Steven M. Ettinger,Jonathan L. Halperin,Judith S. Hochman,Frederick G. Kushner,E. Magnus Ohman,William G. Stevenson,Clyde W. Yancy +27 more
TL;DR: Alice K. Jacobs, MD, FACC, FAHA, Chair Jeffrey L. Anderson, PhD, CCNS, CCRN, FAH, Chair-Elect - The first female FACC-FAHA board member to be elected in the history of the sport.
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Diabetes and atherosclerosis: epidemiology, pathophysiology, and management.
TL;DR: Since most patients with diabetes die from complications of atherosclerosis, they should receive intensive preventive interventions proven to reduce their cardiovascular risk.
References
More filters
Journal ArticleDOI
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
TL;DR: This report supports earlier predictions of the epidemic nature of diabetes in the world during the first quarter of the 21st century and provides a provisional picture of the characteristics of the diabetes epidemic.
Journal ArticleDOI
Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction
TL;DR: It is suggested that diabetic patients without previous myocardial infarction have as high a risk of myocardia infarctions as nondiabetic patients with previous my Cardiac Arrest.
Journal ArticleDOI
Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study.
H D Lewis,J W Davis,Donald G. Archibald,W E Steinke,T C Smitherman,J E Doherty rd,H W Schnaper,M M LeWinter,E Linares,J M Pouget,S C Sabharwal,E Chesler,H DeMots +12 more
TL;DR: The data show that aspirin has a protective effect against acute myocardial infarction in men with unstable angina, and they suggest a similar effect on mortality.
Journal ArticleDOI
Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial.
John A. Cairns,Michael Gent,Joel Singer,K J Finnie,G M Froggatt,D A Holder,G Jablonsky,William J. Kostuk,L J Melendez,M G Myers +9 more
TL;DR: Findings provide strong evidence for a beneficial effect of aspirin in patients with unstable angina and there was no evidence of an interaction between sulfinpyrazone and aspirin.
Journal ArticleDOI
Diabetes and atherosclerosis: an epidemiologic view.
TL;DR: Only a relatively small proportion of the excessive occurrence of ASVD in diabetics can be explained by the effects of diabetes on the levels of general risk factors for ASVD, but the major proportion remains unexplained and must be due to effects of Diabetes itself through mechanisms that are incompletely understood.