Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study
Zitta Barrella Harboe,Reimar W. Thomsen,Anders H. Riis,Palle Valentiner-Branth,Jens Jørgen Christensen,Lotte Lambertsen,Karen A. Krogfelt,Helle Bossen Konradsen,Thomas Benfield +8 more
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TLDR
Analyzing population-based data collected over 30 years in more than 18,000 patients with invasive pneumococcal infection, Zitta Harboe and colleagues find specific pneumococCal serotypes to be associated with increased mortality.Abstract:
Background: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). Methods and Findings: In a nationwide population-based cohort study of IPD in Denmark during 1977–2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio $3, p,0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Conclusions: Specific pneumococcal serotypes strongly and independently affect IPD associated mortality. Please see later in the article for the Editors’ Summary.read more
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Indirect Effects of Pneumococcal Childhood Vaccination in Individuals Treated With Immunosuppressive Drugs in Ambulatory Care: A Case-cohort Study.
Anneke Steens,Anneke Steens,Brita Askeland Winje,Richard A. White,Ingvild Odsbu,Arne Broch Brantsæter,Didrik F. Vestrheim +6 more
TL;DR: IPD incidences declined after PCV introduction in both immunocompetent and iatrogenically-immunosuppressed individuals, underscoring the benefit of childhood vaccination for the entire population.
Journal ArticleDOI
Clinical characteristics, antimicrobial resistance, and risk factors for mortality in paediatric invasive pneumococcal disease in Beijing, 2012–2017
Man Jiang,Xi Wang,Liang Zhu,Yonghong Yang,Ke Yao,Fang Dong,Wei Shi,Qiong Wang,Wenqi Song,Gang Liu +9 more
TL;DR: Wang et al. as mentioned in this paper analyzed clinical characteristics, antibiotic susceptibility, and risk factors for mortality in paediatric invasive pneumococcal disease (IPD) in Beijing, and found that meningitis was the most common clinical manifestation of IPD, and was frequently associated with death.
Dissertation
Respiratory Tract Infections: Aspects of Aetiology, Virulence, and Communicable Disease Control
TL;DR: A retrospective study of IPD demonstrated that pneumococcal serotypes differ regarding their capacity to cause septic shock and, together with age and co-morbidities, have an important impact on outcome.
Journal ArticleDOI
Streptococcus pneumoniae Serotype 3 in Mexico (1994 to 2017): Decrease of the Unusual Clonal Complex 4909 Lineage following PCV13 Introduction
Gabriela Echániz-Aviles,Soraia I. Guerreiro,Soraia I. Guerreiro,Catarina Silva-Costa,Catarina Silva-Costa,Catarina I. Mendes,Catarina I. Mendes,João A. Carriço,João A. Carriço,María Noemí Carnalla-Barajas,Araceli Soto-Noguerón,Maria Elena Velazquez-Meza,José Melo-Cristino,José Melo-Cristino,Antonio Luévanos-Velazquez,Lucía Martínez-Medina,María del Rosario Vazquez-Larios,Mário Ramirez,Mário Ramirez +18 more
TL;DR: Considering the suggestions of a lower efficacy of the 13-valent pneumococcal conjugate vaccine against serotype 3, the different dynamics of the two major serotypes 3 lineages in Mexico following the introduction of PCV13 should be closely monitored.
Journal ArticleDOI
Pneumococcal serotype determines growth and capsule size in human cerebrospinal fluid
Annelies Müller,Anke Salmen,Suzanne Aebi,Linda de Gouveia,Anne von Gottberg,Anne von Gottberg,Lucy J. Hathaway +6 more
TL;DR: It is proposed that serotype-specific differences in disease severity observed in meningitis patients may, at least in part, be explained by differences in growth and capsule size in human cerebrospinal fluid.
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