Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study
Zitta Barrella Harboe,Reimar W. Thomsen,Anders H. Riis,Palle Valentiner-Branth,Jens Jørgen Christensen,Lotte Lambertsen,Karen A. Krogfelt,Helle Bossen Konradsen,Thomas Benfield +8 more
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TLDR
Analyzing population-based data collected over 30 years in more than 18,000 patients with invasive pneumococcal infection, Zitta Harboe and colleagues find specific pneumococCal serotypes to be associated with increased mortality.Abstract:
Background: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). Methods and Findings: In a nationwide population-based cohort study of IPD in Denmark during 1977–2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio $3, p,0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Conclusions: Specific pneumococcal serotypes strongly and independently affect IPD associated mortality. Please see later in the article for the Editors’ Summary.read more
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Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease
TL;DR: The serotypes predominantly affecting patients younger than the remaining collective of patients were 14, 6B, 19F, and 18C, while patients with IPD caused by serotypes 3, 4, and 9V were older than the collective, on average.
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Factors Associated with the Occurrence of Hearing Loss after Pneumococcal Meningitis
Lise Worsøe,Per Cayé-Thomasen,Christian Brandt,Christian Brandt,Jens Thomsen,Christian Østergaard +5 more
TL;DR: Hearing loss is common after pneumococcal meningitis, and audiometry should be performed on all those who survive pneumococ Calcutta meningitas, to identify important risk factors for development of hearing loss.
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Regional epidemiology of invasive pneumococcal disease in Asian adults: epidemiology, disease burden, serotype distribution, and antimicrobial resistance patterns and prevention.
TL;DR: Increased awareness of the public health and economic benefits of pneumococcal vaccination is critically needed to help both the public and policymakers in making changes to vaccination policies in the region.
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The effect of pneumococcal conjugate vaccines on the incidence of invasive pneumococcal disease caused by ten non-vaccine serotypes in Denmark.
TL;DR: Future vaccinations of the young age group alone with a vaccine targeting some of the 10-Non-PCV serotypes may not elicit the desired effect on herd protection since these serotypes are primarily causing IPD among the elderly.
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Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types
Sarah Browall,Erik Backhaus,Pontus Naucler,Ilias Galanis,Karin Sjöström,Diana Karlsson,Stefan Berg,Joachim Luthander,Margareta Eriksson,Carl Spindler,Mikael Ejdebäck,Birger Trollfors,Jessica Darenberg,Mats Kalin,Åke Örtqvist,Rune Andersson,Birgitta Henriques-Normark,Birgitta Henriques-Normark +17 more
TL;DR: Patients infected with non-PCV13 strains had more underlying diseases, were less likely to have pneumonia and, in adults, tended to have a higher mortality, and patients infected with pneumococci belonging to clonal serotypes only expressing non- PCV13 capsules had a higher risk for septicaemia and mortality.
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