Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study
Zitta Barrella Harboe,Reimar W. Thomsen,Anders H. Riis,Palle Valentiner-Branth,Jens Jørgen Christensen,Lotte Lambertsen,Karen A. Krogfelt,Helle Bossen Konradsen,Thomas Benfield +8 more
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TLDR
Analyzing population-based data collected over 30 years in more than 18,000 patients with invasive pneumococcal infection, Zitta Harboe and colleagues find specific pneumococCal serotypes to be associated with increased mortality.Abstract:
Background: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). Methods and Findings: In a nationwide population-based cohort study of IPD in Denmark during 1977–2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio $3, p,0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Conclusions: Specific pneumococcal serotypes strongly and independently affect IPD associated mortality. Please see later in the article for the Editors’ Summary.read more
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Invasive pneumococcal disease among immunocompromised persons: implications for vaccination programs
Altynay Shigayeva,Wallis Rudnick,Karen Green,Danny K. Chen,Walter Demczuk,Wayne L. Gold,Jennie Johnstone,Ian Kitai,Sigmund Krajden,Reena Lovinsky,Matthew P. Muller,Jeff Powis,Neil Rau,Sharon Walmsley,Gregory J. Tyrrell,Ari Bitnun,Allison McGeer +16 more
TL;DR: PCV13 vaccination of immunocompromised adults may substantially reduce the residual burden until herd immunity from pediatric PCV13 is fully established, and both PPV23 and herd Immunity from pediatricPCV7 were associated with reductions in IPD in immunocombromised populations.
Journal ArticleDOI
Safety, Tolerability, and Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine (PCV20) in Adults 60 to 64 Years of Age.
Donald Hurley,Carl Griffin,Mariano Young,Daniel A. Scott,Michael W. Pride,Ingrid L. Scully,John Ginis,Joseph M. Severs,Kathrin U. Jansen,William C. Gruber,Wendy Watson +10 more
TL;DR: PCV20 was well tolerated in adults 60 to 64 years of age, with a safety profile consistent with historical experience of PCVs in this age group, and demonstrates the potential for PCV20 to expand pneumococcal disease protection.
Journal ArticleDOI
Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme.
Zitta Barrella Harboe,Palle Valentiner-Branth,Thomas Benfield,Jens Jørgen Christensen,Peter Henrik Andersen,M Howitz,Karen A. Krogfelt,Lotte Lambertsen,Helle Bossen Konradsen +8 more
TL;DR: The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals, and the case fatality was 17% in both periods.
Journal ArticleDOI
Global prevailing and emerging pediatric pneumococcal serotypes
TL;DR: A comprehensive global summary of the prevailing and emerging serotypes causing IPD in children and the seroprevalence of NVTs after widespread use of PCV10 and PCV13 requires ongoing monitoring is provided.
Journal ArticleDOI
Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection.
TL;DR: There is an urgent need to develop new, effective, and affordable pneumococcal vaccines, which could cover a wide range of serotypes, and the new approaches to develop effective vaccines with broad serotype coverage are discussed.
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