Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study
Zitta Barrella Harboe,Reimar W. Thomsen,Anders H. Riis,Palle Valentiner-Branth,Jens Jørgen Christensen,Lotte Lambertsen,Karen A. Krogfelt,Helle Bossen Konradsen,Thomas Benfield +8 more
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TLDR
Analyzing population-based data collected over 30 years in more than 18,000 patients with invasive pneumococcal infection, Zitta Harboe and colleagues find specific pneumococCal serotypes to be associated with increased mortality.Abstract:
Background: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). Methods and Findings: In a nationwide population-based cohort study of IPD in Denmark during 1977–2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio $3, p,0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Conclusions: Specific pneumococcal serotypes strongly and independently affect IPD associated mortality. Please see later in the article for the Editors’ Summary.read more
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Pan-serotype Reduction in Progression of Streptococcus pneumoniae to Otitis Media After Rollout of Pneumococcal Conjugate Vaccines.
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TL;DR: Current trends and knowledge gaps in CAP management and prevention are summarized, and the effectiveness of the 23-valent pneumococcal polysaccharide vaccine remains debated, and whether the newer conjugate vaccines are more effective remains to be determined.
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TL;DR: A reduction in the incidence of IPD in adults was seen late after the vaccine licensure, both in general population and in ISP, and coverage of PCV13 vaccine might be suboptimal for ISP in the coming years.
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