Journal ArticleDOI
Polarized ethylene. V. Synthesis of 1-substituted indolizine, pyrazolo[1,5-a]pyridine, and their related compounds using methoxyethylene derivatives
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TLDR
The reaction of pyridinium or isoquinolinium N-ylides with methoxy-substituted ethylenes gave the corresponding indolizine and pyrrolo[2,1-a]isoquinoline derivatives bearing acetyl, aroyl, cyano, ester group at the 1-position in one step as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-02-01. It has received 32 citations till now. The article focuses on the topics: Indolizine & Isoquinoline.read more
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Journal ArticleDOI
Unexpectedly cyclized products by reaction of N-tosyliminoisoquinolinium ylides with trimethylsilylketene
TL;DR: In this article, the reaction of N -tosyliminoisoquinolinium ylides with trimethylsilylketene as a C2 unit introducing reagent, giving unexpected [3+2] cycloadducts, pyrazolo[5,1]-isoquinolines, is described.
Journal ArticleDOI
A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process
TL;DR: A novel tandem 1,4-conjugate addition-intramolecular Michael addition [3+2] annulation process for synthesis of the pyrazolo[1,5-a]quinoline ring system is described.
Journal ArticleDOI
2-Alkoxycarbonylpyridinium N-Aminides: 1,3-Dipoles or 1,4-Nucleophile−Electrophile Synthons? Experimental and Theoretical Evidence for the Mechanism of Pyrido[1,2-b]pyridazinium Inner Salt Formation†
Jesús Valenciano,Ana M. Cuadro,Juan J. Vaquero,Julio Alvarez-Builla,Raúl Palmeiro,Obis Castaño +5 more
TL;DR: In this article, a mechanistic investigation performed using both PM3 frontier molecular orbital (FMO) and potential energy surface (PES) analysis at the RHF/6-31+G* level indicates that both the cycloaddition reaction and the ring expansion occur in a concerted way rather than through a stepwise mechanism via a zwitterionic intermediate.
Journal ArticleDOI
Nucleophilic Vinyl Substitution in the Synthesis of Heterocycles. (Review)
TL;DR: In this article, the synthesis of various heterocyclic compounds by the reaction of nucleophiles with electrophilic olefins containing a nucleophilic group is reviewed and analyzed.
Book ChapterDOI
Diacetylene and its derivatives in heterocyclization reactions
TL;DR: In this article, the diacetylene transformations leading to fundamental heterocycles (pyrroles, thiophene, selenophene, tellurophenes, pyrazoles, isoxazoles, pyridines, and pyrimidines) are discussed.
References
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Molecular Orbital Theory of Orientation in Aromatic, Heteroaromatic, and Other Conjugated Molecules
TL;DR: In this article, the LCAO MO treatment of the orientation problem in chemical reactions of π-electron systems is subjected to an extension in the sense that the frontier orbitals are specified according to the type of reaction.
Journal ArticleDOI
Hydroxymethylene Ketones. I. The Preparation of β-Ketodimethylacetals and Methoxymethylene Ketones
E. Earl Royals,Kent C. Brannock +1 more
Journal ArticleDOI
Synthesis of Indolizine Derivatives and Their Related Compounds Using Ketene Dithioacetals
TL;DR: The synthesis of indolizine derivatives and their related compounds using ketene dithioacetals is described in this paper, where the 1, 5-dipolar cyclization is used.
Journal ArticleDOI
1,3‐Dipolare Cycloadditionen, 84. Additionen mit Chinolinium‐, Isochinolinium‐ und Phenanthridinium‐N‐imid2)
TL;DR: In this article, the reactivity of heteroaromatic N-imides and their dimers is discussed, and it is shown that the dimers behave as expected for aromatic azomethine imines as 1,3-dipoles.