Journal ArticleDOI
Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
Jiangfeng Du,Jiangfeng Du,Zhanjun Gu,Liang Yan,Yuan Yong,Xuan Yi,Xiao Zhang,Jing Liu,Renfei Wu,Cuicui Ge,Chunying Chen,Chunying Chen,Chunying Chen,Yuliang Zhao,Yuliang Zhao +14 more
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TLDR
Improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo as a consequence of PVP‐Bi2Se3@Sec NPs treatment.Abstract:
The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2 Se3 nanoparicles (PVP-Bi2 Se3 @Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2 Se3 @Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2 Se3 @Sec NPs during the treatment, which demonstrates that PVP-Bi2 Se3 @Sec NPs have good biocompatibility.read more
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Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
A review on thermally conductive polymeric composites: classification, measurement, model and equations, mechanism and fabrication methods
Xutong Yang,Chaobo Liang,Tengbo Ma,Yongqiang Guo,Jie Kong,Junwei Gu,Junwei Gu,Minjiao Chen,Jiahua Zhu +8 more
TL;DR: In this paper, the authors reviewed recent progress in the classification, measurement methods, model and equations, mechanisms, commonly used thermally conductive fillers, and the correlative fabrication methods for the thermallyconductive polymeric composites, aiming to understand and grasp how to enhance the λ value effectively.
Journal ArticleDOI
The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties
Mohammad-Ali Shahbazi,Mohammad-Ali Shahbazi,Leila Faghfouri,Mónica P. A. Ferreira,Patrícia Figueiredo,Hajar Maleki,Farshid Sefat,Jouni Hirvonen,Hélder A. Santos +8 more
TL;DR: This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions.
Journal ArticleDOI
Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization.
TL;DR: The general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods.
Journal ArticleDOI
X-ray-activated nanosystems for theranostic applications
TL;DR: This review systematically describes the interaction mechanisms between X-rays and nanosystems, and provides an overview of X-ray-sensitive materials and the recent progress on X- Ray-activated nanosSystems for cancer-associated theranostic applications.
References
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Journal ArticleDOI
BSA‐Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy
Yong Wang,Yongyou Wu,Yujing Liu,Jia Shen,Ling Lv,Liubing Li,Liecheng Yang,Jianfeng Zeng,Yangyun Wang,Leshuai W. Zhang,Zhen Li,Mingyuan Gao,Zhifang Chai +12 more
TL;DR: Sub 10 nm Bi2S3 biocompatible particles are prepared through a bovine serum albumin (BSA)‐mediated biomineralization process under ambient aqueous conditions and due to the remarkable photothermal conversion efficiency and large X‐ray attenuation coefficient, the implanted tumors are completely eradicated through combined therapies, which highlights the potential of BSA‐capped Bi2NPs as a novel multifunctional nanotheranostic agent.
Journal ArticleDOI
Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
Yong Wang,Lingbo Liu,Lingbo Liu,Senthil Kumar Pazhanisamy,Hongliang Li,Hongliang Li,Aimin Meng,Aimin Meng,Daohong Zhou +8 more
TL;DR: The results from this study show that exposure of mice to a sublethal dose of total body irradiation (TBI) induced a persistent increase in reactive oxygen species (ROS) production in HSCs only, providing the foremost direct evidence demonstrating that TBI selectively induces chronic oxidative stress in H SCs at least in part via up-regulation of NOX4.
Journal ArticleDOI
Dynamic Diselenide Bonds: Exchange Reaction Induced by Visible Light without Catalysis
TL;DR: This work entails the use of diselenide bonds as dynamic covalent bonds, the development of a dynamic exchange reaction under mild conditions, and an extension of selenium-related dynamic chemistry.
Journal ArticleDOI
Metabolizable Bi2Se3 Nanoplates: Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging
Xiaodong Zhang,Jie Chen,Yuho Min,Gyeongbae Park,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Hao Wang,Wei Long,Jianping Xie,Kai Gao,Lianfeng Zhang,Saijun Fan,Feiyue Fan,Unyong Jeong +14 more
TL;DR: In this article, the liver and spleen are dominant organs for accumulation of the nanoplates, which is mainly due to RES absorption, and the concentration of Bi and Se in tumor tissue continuously increased until 72 h after intraperitoneal injection into mice.
Journal Article
Activity of Methylated Forms of Selenium in Cancer Prevention
Clement Ip,Howard E. Ganther +1 more
TL;DR: The substantial prophylactic efficacy of methylated selenides and the enhancement by arsenite suggest that partially methylated forms of selenium may be directly involved in the anticarcinogenic action of se lenium.